The Artemis exploration zone is a geologically-complex region likely hosting some of the oldest and as-yet-unstudied materials on the Moon. We review six potential Artemis landing sites (001, 004, 007, 011, 102, and 105) within candidate Artemis III landing regions ‘Connecting Ridge,’ ‘Peak Near Shackleton,’ ‘Leibnitz Beta Plateau,’ ‘de Gerlache Rim,’ and ‘de Gerlache Rim 2.’ Kaguya Spectral Profiler mineral data were used to determine average lithological composition at each landing site. Potentially accessible geologic materials, their ages and significance, and appropriate application of radiometric chronometers are discussed in reference to return samples from each potential landing site. Chronologic analyses of return samples from the Artemis exploration zone will enable the anchoring of the lunar impact flux curve, determine the absolute timing of pivotal events in lunar geologic history, and reveal geological diversity of the differentiated lunar body.