We present the case of a 55-year old male patient who developed hyperkalemia after using Cotrimoxazole(TMP-SMX).He developed an elevated level of potassium from day-4 which kept on increasing until the drug was withheld on day-8.There was a marked increase in levels from 3.0(baseline) to 6.2 before the drug was withheld.

Recently, an infinitesimal approach for finding reciprocal transformations has been proposed. The method uses the group analysis approach and consists of similar steps as for finding an equivalence group of transformations. The new method provides a systematic tool for finding classes of reciprocal transformations (group of reciprocal transformations). Similar to the classical group analysis this approach can be also applied for finding all reciprocal transformations (not only composing a group) of the equations under study. The present paper provides this algorithm. As an illustration, the method is applied to the two-dimensional stationary gas dynamics equations. Equivalence group, group of reciprocal transformations and completeness of all discrete reciprocal transformations are presented in the paper. The results are stated in form of a theorem.

The low Mach number limit of the nonisentropic compressible Hookean elastodynamic equations is rigorously proved with respect to well-prepared initial data. We introduce certain suitable seminorms to obtain the uniform estimate of solutions, for which the critical point is to cancel the higher order derivate terms caused by the coupling of velocity and deformation gradient.

Abstract. In this manuscript we consider the internal control problem for the fifth order KdV type equation, commonly called the Kawahara equation, on unbounded domains. Precisely, under certain hypotheses over the initial and boundary data, we are able to prove that there exists an internal control input such that solutions of the Kawahara equation satisfies an integral overdetermination condition. This condition is satisfied when the domain of the Kawahara equation is posed in the real line, left half-line and right half-line. Moreover, we are also able to prove that there exists a minimal time in which the integral overdetermination condition is satisfied. Finally, we show a type of exact controllability associated with the “mass” of the Kawahara equation posed in the half-line.

Gobbling activity of Eastern wild turkeys (Meleagris gallopavo silvestris; hereafter, turkeys) has been widely studied, focusing on drivers of daily variation. Weather variables are widely believed to influence gobbling activity, but results across studies are contradictory and often equivocal, leading to uncertainty in the relative contribution of weather variables to daily fluctuations in gobbling activity. Previous works relied on road-based auditory surveys to collect gobbling data which limits data consistency, duration, and quantity due to logistical difficulties associated with human observers and restricted sampling frames. Development of new methods using autonomous recording units (ARUs) allows researchers to collect continuous data in more locations for longer periods of time, providing the opportunity to delve into factors influencing daily gobbling activity. We used ARUs from 1 March to 31 May to detail gobbling activity across multiple study sites in the southeastern United States during 2014 – 2018. We used state-space modeling to investigate the effects of weather variables on daily gobbling activity. Our findings suggest rainfall, greater wind speeds, and greater temperatures negatively affected gobbling activity, whereas increasing barometric pressure positively affected gobbling activity. Therefore, when using daily gobbling activity to make inferences relative to gobbling chronology, reproductive phenology, and hunting season frameworks stakeholders should recognize and consider the potential influences of extended periods of inclement weather.

Far migrated IUCD is an uncommon condition that has different manifestations depending upon its location. We present the case of a 22-year-old primipara who had a spontaneous abortion after IUCD placement and suffered chronic right lower abdominal pain thereafter. Diagnostic laparoscopy revealed Cu-IUCD in the right iliac fossa.

A 5-month-old German Shepherd dog was presented with cluster seizures. MR imaging showed a large irregular pseudomass in the central region of the cranial cavity, compatible with a malformation of cortical development (MCD). Despite the extensive changes, the patient was neurologically normal interictally one year following diagnosis.

The strong core base in chemical engineering during the latter half of the 20th century enabled chemical engineers to contribute extensively to many areas outside of the traditional. The depth of such involvement has led researchers to confront questions much more engaging to the field of application, thus adopting and cultivating expertise more native to it than to secure chemical engineering as a discipline. The progress of knowledge in science and engineering must leave a strong trail of fundamental understanding through developed methodologies that can assist in continuing progress. If this tenet is acknowledged, this article yields considerable scope for discussion on whether chemical engineering research is continuing to provide for a growing core that has endowed chemical engineers with the ability to formulate and solve important societal problems in which material systems undergo changes in composition and energy. We discuss opportunities for hopefully serving the issues of concern.

The dynamic transitions of the Brusselator model has been recently analyzed in Y. Choi et’al (2021) and T. Ma, S. Wang (2011). Our aim in this paper is to address the relation between the pattern formation and dynamic transition results left open in those papers. We consider the problem in the setting of a 2D rectangular box where an instability of the homogeneous steady state occurs due to the perturbations in the direction of several modes becoming critical simultaneously. Our main results are two folds: (1) a rigorous characterization of the types and structure of the dynamic transitions of the model from basic homogeneous states and (2) the relation between the dynamic transitions and the pattern formations. We observe that the Brusselator model exhibits different transition types and patterns depending on the nonlinear interactions of the pattern of the critical modes.

Myositis is one of the uncommon adverse events following COVID--19 vaccination, and its mechanism is still unclear. In the hope of aiding in its better understanding, we present a case of myositis following the first dose of the ChAdOx1 nCoV-19 Corona Virus Vaccine, evidenced by serology and MRI.

Computational models are increasingly used to investigate and predict the complex dynamics of biological and biochemical systems. Nevertheless, governing equations of a biochemical system may not be (fully) known, which would necessitate learning the system dynamics directly from, often limited and noisy, observed data. On the other hand, when expensive models are available, systematic and efficient quantification of the effects of model uncertainties on quantities of interest can be an arduous task. This paper leverages the notion of flow-map (de)compositions to present a framework that can address both of these challenges via learning data-driven models useful for capturing the dynamical behavior of biochemical systems. Data-driven flow-map models seek to directly learn the integration operators of the governing differential equations in a black-box manner, irrespective of structure of the underlying equations. As such, they can serve as a flexible approach for deriving fast-to-evaluate surrogates for expensive computational models of system dynamics, or, alternatively, for reconstructing the long-term system dynamics via experimental observations. We present a data-efficient approach to data-driven flow-map modeling based on polynomial chaos Kriging. The approach is demonstrated for discovery of the dynamics of various benchmark systems and a co-culture bioreactor subject to external forcing, as well as for uncertainty quantification of a microbial electrosynthesis reactor. Such data-driven models and analyses of dynamical systems can be paramount in the design and optimization of bioprocesses and integrated biomanufacturing systems.

Vaping associated lung injury (EVALI) has increased in prevalence after first being noted in an outbreak among teenagers in 2019. Vaping involves the use of a heating device to aerosolize a product, typically nicotine or more recently, cannabinoids. Products that contain cannabinoids, such as CBD oil, are being used more as these products are easy to obtain and are typically less expensive. The clinical manifestations of EVALI are widespread and include respiratory symptoms as well as cardiogenic, gastrointestinal, and constitutive symptoms. EVALI rarely presents with hemoptysis as one of the main presenting symptoms, especially in an adolescent. This case will discuss EVALI with associated hemoptysis in a teenager secondary to vaping cannabinoid oil.

Rationale: Animal models suggest pre-eclampsia (Pre-E) affects alveolar development, but data from humans are lacking. Objective: Assess the impact of Pre-E on airway function, diffusion capacity, and respiratory morbidity in preterm and term infants born from mothers with Pre-E. Methods: Infants born from mothers with and without Pre-E were recruited for this study; term and preterm infants were included in both cohorts. Respiratory morbidity in the first 12 months of life was assessed through monthly phone surveys. Raised volume rapid thoracoabdominal compression and measurement of diffusion capacity of the lung to carbon monoxide (DLCO)) were performed at 6 months corrected age. Results: There were 146 infants in the Pre-E cohort and 143 in the control cohort. The Pre-E cohort was further divided into non-severe (N=41) and severe (N=105) groups. There was no significant difference in DCLO and DLCO/aveolar volume amongst the three groups. Forced vital capacity was similar amongst the three groups, but the non-severe Pre-E group had significantly higher forced expiratory flows that the other two. After adjusting for multiple covariates including prematurity, the severe Pre-E group had a lower risk for wheezing in the first year of life compared to the other two. Conclusions: Pre-E is not associated with reduced DLCO, lower forced expiratory flows, or increased wheezing in the first year of life. These results differ from animal models and highlight the the complex relationships between Pre-E and lung function and respiratory morbidity in human infants.

Understanding how populations diverge and new species arise is a central question in evolutionary biology. ‘Allopatric’ divergence through geographic isolation is considered to be the commonest mechanism generating species biodiversity in mountainous ecosystems. However, the underlying genomic dynamics, especially genomic islands of elevated divergence and genes that are highly diverged as a result of lineage-specific selection, remain poorly understood. Stellera chamaejasme is widely distributed on the Qinghai-Tibet Plateau and in adjacent regions, making it a good model with which to explore genomic divergence in mountainous ecosystems. We assembled a high-quality, chromosome-level genome for this species and re-sequenced the genomes of 24 populations across its distributional range. Our population genomic analyses recovered four distinct genetic lineages corresponding to geographic distributions with contrasting environments. However, we revealed that continuous gene flow occurred during the diversification of these four lineages and inter-lineage hybrids, and plastome introgressions were frequently found in regions of contact. The elevated genomic divergences were highly heterogeneous across the genome. The formation of such genomic islands showed neither correlation with rate of gene flow nor relationship to time of divergence. The lineage-specific positively selected genes potentially involved in local adaptation were found both within and outside genomic islands. Our results suggest that genomic divergence in S. chamaejasme is likely to have been triggered and further maintained by local selection in addition to geographic isolation.

The rapid and successful strides in quantum chemistry in the past decades can be largely credited to a conspicuous synergy between theoretical and computational advancements. However, the architectural computer archetype that enabled such a progress is approaching a state of more stagnant development. One of the most promising technological avenues for the continuing progress of quantum chemistry is the emerging quantum computing paradigm. This revolutionary proposal comes with several challenges, which span a wide array of disciplines. In chemistry, it implies, among other things, a need to reformulate some of its long established cornerstones in order to adjust to the operational demands and constraints of quantum computers. Due to its relatively recent emergence, much of quantum computing may still seem fairly nebulous and largely unknown to most chemists. It is in this context that here we review and illustrate the basic aspects of quantum information and their relation to quantum computing insofar as enabling simulations of quantum chemistry. We consider some of the most relevant developments in light of these aspects and discuss the current landscape when of relevance to quantum chemical simulations in quantum computers.

This report presents a man with a huge coronary fistula, connecting Left Circumflex coronary artery to right ventricle. During the follow-up, the patient developed progressive symptoms of heart failure nonresponsive to medical treatment. Therefore, an endovascular closure with vascular plug was successfully done for him.

COVID-19 showed different characteristics and many cases showed clinical manifestations that could not be attributed to other conditions. We present a 22-year-old female had an uneventful recovery from COVID-19 and after that, she developed a cytokine storm and a worsening clinical condition two days after dental root canal therapy.

Bile leak after cholecystectomy is associated with significant comorbidity. Biliary duct variant anatomy can complicate identification and management. We report a very rare presentation of recurrent delayed bile leaks years after laparoscopic cholecystectomy secondary to missed right posterior sectoral bile duct injury. Surgical intervention was required after failure of conservative management.Key clinical message: Right posterior sectoral duct injury should be considered in patients presenting with a delayed recurrent bile leak. Deep dissection into liver parenchyma during gallbladder fossa dissection should be avoided to prevent occurrence of such injuries.