Colistin Induced Neurotoxicity in a Multidrug Resistant UTI: a case report

Late-Onset Third Degree Atrioventricular Block in adult with surgically corrected Ebstein Anomaly: A Case report

Title:Diagnostically Challenging case of SLE with Concurrent Wilson’s Disease in Young Girl- A case report

Introduction:Teeth that exceed the average number are referred to as supernumerary teeth. Although the exact reason of an excess teeth is unknown, it is thought that both hereditary and environmental factors are involved. Mesiodens, or extra teeth, are most frequently found in the maxillary midline (1). According to reports, the frequency of mesiodens ranges from 0.1% to 7.0% (2). A number of issues, including diastema, crowding, resorption of the roots of nearby permanent teeth, dentigerous cysts, and problems with maxillary incisor eruption, can result from mesiodens. Morphologically, mesiodens may have heterogeneous forms. Three common types have been described: conical or peg-shaped, bulbous, and supplementary (tooth-shaped), of which conical is the most common (3). Surgery will be more difficult if the inverted mesiodens is not found quickly. Therefore, it is essential to identify the mesiodens in advance and extract it at the right time to avoid such problems (4).Pre-eruptive intracoronal dentine radiolucency/resorption (PEIR) is defined as a well-bounded, irregular, radiolucent range that extends into distinct dentinal profundities in unerupted teeth and is located inside the coronal section of the tooth, close to the dentin-enamel junction (5). This disorder may be a rare anomaly that affects both primary and permanent dentitions. These abandoned cases were referred to as ”pre-eruptive caries” or ”hidden caries” in the past, since they were not visible. During normal dental radiography examinations, these injuries are often discovered unintentionally, and around 61% of dentists are aware that PEIR can be misdiagnosed (6). The type of radiograph used for assessment, age, sex, and dentition type all affect the occurrence of pre-eruptive caries in teeth, which ranges from 0.25 to 3.5%. Pre-eruptive caries lesions have been commonly seen in molars and premolars. Involvement in one tooth is more often, but cases with several teeth have also been reported (7).Although odontomas can occur at any age, the majority are discovered during the first 20 years of life. Most lesions are seen on regular radiographs, and there is no preference for one gender over another (8). Although afflicted patients rarely exhibit clinical symptoms, they may do so when a permanent tooth or more teeth fail to erupt. Odontomas can occasionally protrude into the oral cavity (9). Complex odontomas seem to favor the posterior mandible, whilst compound odontomas are more frequently detected in the front maxilla. Although odontomas are usually minor, they can occasionally enlarge and cause the bone to expand (10).This paper reports a case involving the presence of a mesiodens in the maxillary midline, a complex odontoma in the right mandible, and radiolucency in the crown region of six unerupted teeth, which is suspicious for pre-eruptive caries.

Anesthesia management of a patient with PDA and Eisenmenger’s Syndrome: a case report

Shrub encroachment can alter the structure and function of grassland ecosystems, leading to their degradation. Therefore, population regeneration dynamics after shrub encroachment on the influence of grassland should not be ignored. H. rhamnoides, as a pioneer species, has significantly encroached with large areas onto the Qinghai-Tibetan Plateau (QTP) due to climate change and over-grazing. However, few studies have focused on the dynamics of population regeneration following successful encroachment. Therefore, we studied H. rhamnoides natural population in the alpine grasslands, investigating population regeneration pattern, seed, bud production and storage, and limitation imposed by microhabitats (soil, light and feeding). Our aim was to explore population regeneration strategies and identify key limiting factors for population regeneration after successful encroachment. Our findings revealed several key points: (i) H. rhamnoides entered the alpine grassland by relying on seeds, it would seize resources by low-cost clonal reproduction, then increase sexual reproduction to improve genetic diversity. (ii) The production and storage of seeds and buds was sufficient, seed vigor was high, seed emergence rate was higher duo to mechanical restriction of hard seed coat was weakened by the water transport channels in the palisade layer, and formation of seedlings was less restricted. (iii) H. rhamnoides population regeneration was mainly limited by microhabitats light and feeding. However, light and feeding significantly affected seedlings photosynthesis and carbon storage, their interaction significantly reduced the seedlings survival, and further restricted population regeneration. The results can provide theoretical basis for the restoration and management of alpine grassland degradation caused by shrub encroachment.

Solid oxide fuel cells (SOFCs) are widely presented as a sustainable solution to future energy challenges. Nevertheless, SOFCs presently rely on significant use of several critical raw materials to enable optimised reaction kinetics at the device electrodes. This challenge can be addressed through the use of thin-film electrode materials, however this is typically accompanied by complex device fabrication procedures as well as poor mechanical and chemical stability. In this work, we conduct a systematic study of a range of promising thin-film electrode materials based on vertically aligned nanocomposite (VAN) thin films. We demonstrate low area specific resistance (ASR) values of 0.44 cm2 at 650° C can be achieved using (La0.60Sr0.40)0.95Co0.20Fe0.80O3 - (Sm2O3)0.20(CeO2)0.80 (LSCF-SDC) thin films, which are also characterised by a low degradation rate, approximately half that of planar LSCF thin films. We then integrate these LSCF-SDC VAN films directly with commercial anode supported half cells through a single step deposition process. The resulting cells exhibit peak power density of 0.47 W/cm2 at 750° C, competitive with 0.64 W/cm2 achieved for the same cells operating with a bulk LSCF cathode despite 99.5% reduction in cathode critical raw material use. Therefore, the present work marks a valuable step towards the sustainable proliferation of SOFC technology.

Thermoelectric coolers utilizing the Peltier effect have dominated the field of solid-state cooling but their efficiency is hindered by material limitations. Alternative routes based on the Thomson and Nernst effects offer new possibilities. Here, we present a comprehensive investigation of the thermoelectric properties of 1T-TiSe2, focusing on these effects around the charge density wave (CDW) transition (≈ 200 K). The abrupt Fermi surface reconstruction associated with this transition leads to an exceptional peak in the Thomson coefficient of 450 μV.K−1 at 184 K, surpassing the Seebeck coefficient. Furthermore, 1T-TiSe2 exhibits a remarkably broad temperature range (170 − 400 K) with an average Thomson coefficient exceeding 190 μV.K−1, a characteristic highly desirable for the development of practical Thomson coolers with extended operational ranges. Additionally, the Nernst coefficient exhibits an unusual temperature dependence, increasing with temperature in the normal phase, which we attribute to bipolar conduction effects. The combination of solid-solid pure electronic phase transition to a semimetallic phase with bipolar transport is identified as responsible for the unusual Nernst trend and the unusually large Thomson coefficient over a broad temperature range.

Background Equine dental diseases significantly impact on a horse’s overall health, performance, and quality of life. They can result in secondary infections and digestive disturbances, potentially leading to colic. A recently described disease affecting the incisors of horses is equine odontoclastic tooth resorption and hypercementosis (EOTRH). Understanding EOTRH is crucial for early diagnosis, effective management, and prevention of its severe consequences. Objectives To determine proteomic differences in incisor cementum in horses with and without clinical EOTRH. Study Design Comparative and observational clinical study. Methods Teeth were extracted and cementum was isolated using a diamond wire. Proteins were extracted using an optimised sequential workflow, and trypsin digested for mass spectrometry. Protein identification and label-free quantification was undertaken. Results In total 1149 unique proteins were detected in cementum across all samples. We identified four proteins exclusively in EOTRH affected cementum. EOTRH samples showed a higher heterogeneity than healthy samples. In total 54 proteins were increased in EOTRH, and 64 proteins were reduced (adjusted p-value < 0.05). Inflammatory proteins, such as cathepsin G (p = 0.004), neutrophil elastase (p = 0.003), bactericidal permeability-increasing protein (p = 0.002), azurocidin (p = 0.003) and lactotransferrin (p = 0.002) were all increased in EOTRH. Pathway analysis revealed that antimicrobial peptides (Z score 2.65, p = 1.93E-09) and neutrophil degranulation (Z-score 1.89, p = 1.7E-04) were commonly up-regulated canonical pathways. Main limitations The sample size was limited. Conclusion EOTRH leads to biochemical changes within the cementum proteome, which are important in explaining the physiological changes occurring in disease. Differentially abundant proteins may represent promising biomarkers for earlier disease detection and establishment of a cell-based model could provide further insight into the role these proteins play in hypercementosis.

Public security is a crucial aspect of maintaining social order. Although crime rates in western cultures may be considered socially acceptable, it is important to continually improve security measures to prevent potential risks.  With the advancements in artificial intelligence methods, particularly in deep learning and computer vision, it has become possible to detect abnormal event patterns in groups of people. This paper presents a systematic review of deep learning techniques employed for identifying gatherings of people and detecting anomalous events to enhance public security. Some of the open research areas are identified, including the lack of works addressing multiple cases of anomalies in large concentrations of people, which leaves open an important avenue for future scientific work.

Therapeutic levels of Acetaminophen causing AKI: A case report and literature reviewHamnah Tayyab, M.D1, Lavanya Dhondapati, M.D2, Ashraf Ullah, M.D3, Mohammed Dheyaa Marsool Marsool, MBCHB4, Singh Jagmeet, M.D5, Khabab Abbasher Hussien Mohamed Ahmed, MBBS61Guthrie/Robert Packer Hospital, Sayre, PA, USA, Email: [email protected]/Robert Packer Hospital, Sayre, PA, USA, Email: [email protected] Liver Research Centre, Beth Israel Deaconess, Boston, MA, USA, Email: [email protected] Medicine, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq, Email: [email protected]/Robert Packer Hospital, Sayre, PA, USA, Emai: [email protected] Faculty of Medicine, University of Khartoum, Khartoum, Sudan, Email: [email protected] ,

Title: B-cell acute lymphoblastic leukemia following refractory multiple myelomaRunning title: ALL following refractory MMKey words: B-cell leukemia, myeloma, cytologyAuthors list : Radu Chiriac1, Valentin Pourchet11Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Laboratoire d’hématologie biologique, Pierre-Benite, FranceCorresponding author: Radu Chiriac ; Hospices Civils de Lyon, 69495 Pierre-Benite Cedex-France ; Tel: (33) 4 78 56 90 20; Fax: (33) 4 78 86 33 40 ; Email: [email protected] contributions: RC and VP wrote the manuscript and conducted the cytological and cytometry studies. All authors contributed to the final manuscript.Data availability statement: Data sharing is not applicable to this article as no new data were created or analysed in this study.Funding statement: n/aConflict of interest statement: The authors have no conflict of interestEthics approval statement: This manuscript respects the ethic policy of CHU Lyon for the treatment of human research participants.Patient consent statement: No patient-identifying data were used. Written informed consent was obtained from the patient to publish this report in accordance with the journal’s patient consent policyPermission to reproduce material from other sources: The authors declare no use of third-party material in this study for which formal permission is requiredClinical trial registration : n/aWord count : 347Table count : 0Figure count : 1

IntroductionHematological malignancies (HMs) are a group of malignant clonal disorders that mainly affect the blood and hematopoietic tissues. They are broadly categorized into myeloid and lymphoid lineages \RL (1)\RL. Acute lymphoblastic leukemia (ALL) is classified as acute \RL lymphoid lineage disorder. All hematological malignancies engage the immune system and raise the chances of opportunistic infections mainly invasive fungal infections \RL)IFIs\RL( (2).Aspergillus and Mucorales species are emerged as increasingly relevant and most common agents responsible for highly lethal IFIs (3). The implementation of prophylaxis targetingCandida species in individuals with HMs has resulted in a higher occurrence of Aspergillosis compared to Candida infections (4).Aspergillus spp., the airborne microorganisms, can manifest in three principal forms: invasive, saprophytic, and allergic (5). AlthoughAspergillus fumigatus (A. fumigatus ) is the predominant species associated with disease, other species can also result in invasive infections in profound immunocompromised patients (6). Statistics indicate that invasive aspergillosis occurs in 4-15% of cases and has a mortality rate between 60% and 85% (7). Mucormycosis, a less frequent occurrence compared to aspergillosis, is a devastatingly angioinvasive fungal infection caused by ubiquitous filamentous fungi belonging to the Mucorales order (8). The main damage is rhino-orbital-cerebral, pulmonary, gastrointestinal, cutaneous, and disseminated, with a high mortality rate, estimated between 32% and 70% (9). Although lung is the most prevalent site of infection in patients with hematologic malignancies, rhino-orbito-cerebral mucormycosis (ROCM) is the most common form classically described in diabetic patients (10).Severe neutropenia (absolute neutrophil count below 500 cells/mm3) due to toxic antineoplastic chemotherapies and myelosuppressive agents or allogeneic hematopoietic stem cell transplantation (allo-HSCT) placing HMs at a higher risk of evolving life-threatening infections with few symptoms (11).Herein we report a case of concomitant acute invasive fungal rhinosinusitis (AIFR) and invasive pulmonary fungal infection withAspergillus and Mucoraceae species in a patient with pre B cell ALL. This research was approved by the Ethics committee of Isfahan University of medical sciences (IR.ARI.MUI.REC.1403.094), and written informed consent was obtained from the patient.

Introduction:Bacterial bloodstream infections (BSI) account for approximately 20 – 30% of all febrile neutropenic episodes in adults with malignancy. (1) There has been a shift in aetiology of BSI from Gram-positive to Gram-negative organisms depending on the geographic area. (2) In cancer patients, the Peripherally Inserted Central Venous Catheter Related Bloodstream Infection (PICCR-BSI) incidence rate is 2.6 per 1000 catheter days, 78% of which are mainly caused by Gram-negative bacteria and 43% are caused by Gram-positive bacteria. (3) Raoultella planticola (R. planticola) is a gram-negative, aerobic, nonmotile bacterium that can be found in soil and water. Urine, faeces, and sputum of 9 – 18% of humans have R. planticola colonization. Although both immunocompetent and immunocompromised persons can develop R. planticola bacteraemia, 82.4% of patients are immunocompromised. (4) There have been multiple case reports of urinary tract infections and a few reports of bacteraemia with R planticola as the cause.

Authors:Mohammed Suliman Alhuwaiti, Consultant, Department of Pediatric Urology, MMCH Hospital, Madinah, Saudi ArabiaSara Ibrahim Almuzaini, Urology resident, Department of Pediatric Urology, MMCH Hospital, Madinah, Saudi ArabiaEkram Awwadh Almutairi, Urology resident, Department of Pediatric Urology, MMCH Hospital, Madinah, Saudi ArabiaSami Abdullah AlRasheedi, Consultant, Department of Pediatric Urology, MMCH Hospital, Madinah, Saudi ArabiaFaris Fatim Alharbi, Consultant Department of Pediatric Urology, MMCH Hospital, Madinah, Saudi ArabiaTaha Alkharawi, Consultant, Department of Pediatric Surgery, MMCH Hospital, Madinah, Saudi ArabiaCorresponding author:Mohammed Suliman Alhuwaiti, Consultant, Department of Pediatric Urology, MMCH Hospital, Madinah, Saudi [email protected]

Title: Traumatic Transmesenteric Hernia Leading to Ischemic Enterocolitis in an Adolescent- Case Report.

Iris longnanensis Z.F. Bai, Y.E. Xiao, F.Y. Yu (Iridaceae: subgenus Iris section Pseudoregelia), a novel herbaceous species native to the arid and thermal valleys of Longnan city, Gansu province, China, is herein described and illustrated. Morphologically akin to I. leptophylla Lingelsheim, I. longnanensis is distinguished by its dense, persistent foliage and strikingly short new leaves (6.6–15.1 cm) during the blooming season, along with its distinctive purplish-brown flowering stem. Phylogenetic analyses based on chloroplast DNA sequences corroborate the classification of I. longnanensis within section Pseudoregelia, highlighting the significance of this new species discovery for understanding the evolution and diversity within the genus.

Root rot is one of the most threatening diseases to pea production. Root rot is caused by several interacting soil-borne pathogens, which makes it challenging to manage. Breeding for resistance is a promising approach for sustainable pea production. While quantitative trait loci (QTL) for resistance against individual pathogens have been identified, the genetic basis underlying resistance against the pathogen complex is poorly understood. Using a previously described diverse panel of 254 pea genotypes and 18k single nucleotide polymorphism (SNP) markers, we identified a novel QTL for resistance to root rot on chromosome chr6LG2. This QTL co-locates with a mitochondrial Rho GTPase and an F-box gene model, which are promising candidates for disease control. A whole-genome prediction model explained up to 53% of the phenotypic variation and reached predictive abilities of up to 0.51 for root rot-related traits. We found that plant height and shoot biomass were unreliable plant health indicators. Instead, these traits were related to the Mendelian Le locus, which controls stem length. Our results provide new insights into the genetic basis of quantitative root rot resistance in pea and provide novel tools that could accelerate the development of resistant pea lines through marker-assisted and genomic selection.