Eagle’s syndrome a rare cause of neck pain: a case report

Hypereosinophilia Associated With Antisynthetase Syndrome With anti-Ro52/PL12 Co-Positivity: An Unusual PresentationKapuczinski A.1, Demeulenaere N.1, Rossi C.2, Bondue B.3, Léon M.11Rheumatology Department, CHU HELORA site Kennedy, Mons, Belgium; 2Infectious Disease Department, CHU HELORA site Kennedy, Mons, Belgium, 3Pneumology Department, Hôpital Erasme, Bruxelles, Belgium.Correspondence : Abeline Kapuczinski; [email protected]

To study on the proteome and to investigate the immune response mechanisms in P. skrjabini infection. Serum samples were randomly collected from patients with P. skrjabini infection and healthy individuals in Guizhou Province. ITRAQ (Isobaric Tags for Relative and Absolute Quantitation) assays were utilized for the analysis of protein catalogs in serum samples. Bioinformatics analysis on the differed proteins was performed. River crabs were sampled from the patients’ habitats, Paragonimus metacercariae were isolated for subsequent rat experimental infection. White blood cells and serum were collected at 42 days post-infection, changes in the expression of IL-4 were assessed. In result, a total of 50 proteins were identified. Typically, increased expression neutrophil defensin 3, protein S100-A9 (S100A9) and serum amyloid A-1 protein (SAA1) were found. S100A9 and SAA1 were involved in the main network but DEFA3 was not. The interaction networks were constituted with the core of Apolipoproteins family and the interactions with the fibrinogen and fibrinolytic system. Through subsequent experimental infections in rats, the expression of Th2 cytokines IL-4 remains unaltered. In conclusion, neutrophils may play a pivotal role in the elimination of parasites, whereas host Th2 cell immune response is suppressed in eliminating worms.

Magnetothermal neuromodulation is a minimally-invasive, deep-brain accessible and tether-free technique. The precisely timed activation of thermosensitive ion channels, such as TRPV1, with local heat generated using magnetic nanoparticles is crucial for efficient neuromodulation. Nevertheless, this technique is greatly hindered by its long stimulus-response time and high safety risks due to the poor heat-generating performance of the nanomediators. Herein, we report the establishment of a ferrimagnetic vortex iron oxide nanoring (FVIO)-mediated magnetothermal neurostimulation technique that is efficient and safe. Compared with widely used superparamagnetic iron oxide nanomediators (SPIOs), the FVIOs triggered Ca2+ influx into HEK293T cells and cortical neurons at an Fe concentration of 54 μg/mL, which is 20.27-fold lower than that needed for SPIOs. In vivo magnetothermal stimulation in the central nucleus of the amygdala of mice further demonstrated that FVIOs with the optimal dose of 0.05 μg evoked fear behaviors with an average latency of 2.51 s, which was 2.3-fold faster than that in the SPIO (0.8 μg)-treated group. More importantly, FVIOs-mediated stimulation not only exhibited negligible histopathological alterations and proinflammatory cytokine expression, but also successfully elicited fear behaviors in transgene-free mice. The FVIO-mediated efficient and safe neuromodulation has the potential for future neuroscience exploitation and neurological disease treatment.

Non-invasive brain stimulation (NIBS) is an emerging treatment for mental disorders that is painlessness and easy to administer. However, its effectiveness for treating fear extinction requires further elucidation. We searched eight bibliographical databases and identified randomized controlled trials of NIBS interventions for fear extinction in healthy populations. Outcomes were evaluated based on skin conductance response (SCR) under three experimental conditions: threat condition stimulation (CS+), safe condition stimulation (CS−), and their discrimination (CS+ minus CS−). We applied a random-effects model to determine effect sizes (Hedge’s g) post-intervention and assessed article quality using Physiotherapy evidence database (PEDro) scale. Twenty-one studies meeting systematic review criteria were included in this analysis, incorporating 40 independent effect sizes and data from 11 studies (n = 632) in the meta-analysis. Compared with the control group, the intervention group exhibited significant reductions SCRs: CS+ (g = −0.32, 95% confidence interval (CI) [−0.56, −0.07]) and discrimination (g = −0.35; 95% CI [−0.55, −0.15]). Fear extinction was more effective in the 24-hour test than immediately after NIBS. In conclusion, NIBS enhanced fear extinction, and the time interval between stimulus and testing may serve as a moderating variable.

Introduction :Chronic cholecystitis is a common gastrointestinal pathology all around the world.1 Hyalinizing cholecystitis (HC) was first described by Patel et al characterizes by dense paucicellular hyalinizing sclerosis effacing the gall bladder wall transforming it into a thin uniform band.2 It is recognized as a distinct entity compared to the more heavily calcified “porcelain” gallbladder (PGB).3 Although traditionally associated with higher risk of gallbladder carcinoma (GBC), the association of PGB has recently been brought into question.4,5 On the other hand HC, reported in about 1.6% of cholecystectomy specimens is more consistently associated with GBC.2 Hence identification of radiological as well as histopathological features of HC along with close follow up of patients even after surgery is imperative.

A Case of Breast Filariasis Diagnosed on Fine Needle Aspiration CytologyBirhanu Kassie Reta1 , Biruk Legesse Tadesse2, Eleni Getahun Kebede3, Atsede Birhanu Worku3, Michael Teklehaimanot Abera4Aksum University College of Health Science, Department of Pathology, Aksum, EthiopiaArsi university College of health Science, Department of Pathology, Asella, EthiopiaWoldia University, Woldia, EthiopiaAddis Ababa University, College of Health Sciences, Addis Ababa UniversityAuthors contact Address1. Birhanu Kassie Reta, MD,[email protected] (ORCHID ID: 0009-0001-1897-9072)2.. Biruk Legesse Tadesse, MD, [email protected](ORCHID ID: 0000-0001-6889-5320)3. Eleni Getahun Kebede, MD, [email protected] (ORCHID ID: 0009-0004-8676-1691)4. Atsede Birhanu Worku, MD, [email protected]( ORCHID ID: 0009-0006-0050-9634)5. Michael Teklehaimanot Abera, MD [email protected], [email protected]

not-yet-known not-yet-known not-yet-known unknown The brush straw checkerboard barrier offers a novel approach to sand control and features 60% higher design efficiency and a longer lifespan of 6 years compared to the traditional artificial straw checkerboard barrier. The wind tunnel test and field observation confirmed that the brush straw checkerboard barrier has high sand fixation efficiency. But how do these two sand barriers perform in terms of restoring soil function? How does the effectiveness of restoring soil function change as the service life of the straw checkerboard barrier increases? These questions still need to be clarified further. This study, conducted in Zhongwei, Ningxia, China, examined plots with brush straw checkerboard barrier, artificial straw checkerboard barrier, and bare sand. The results show that the brush straw checkerboard barrier is superior in improving soil moisture, organic matter, total nitrogen and electrical conductivity compared to the artificial straw checkerboard barrier. In addition, the brush straw checkerboard barrier has a positive impact on microbial diversity and community composition. Increasing sand fixation year through the brush straw checkerboard barrier correlates with improved soil properties and microbial indexes, suggesting that it has the potential for widespread application in desertification mitigation.

Abstract: Recent research has shown a strong link between Th17 cells and their cytokine IL-17, and various cardiovascular diseases such as myocarditis, myocardial infarction, and atherosclerosis. Moreover, Th17 cell signalling is likely to be a key factor in cardiovascular disease. Here, we summarize recent advances in the source, function, regulation, and the effects of Th17 signaling in cardiovascular disease. Research on Th17 will suggest more specific strategies to manipulate these functions. Thus, effective treatment of cardiovascular disease and future clinical treatment will be possible.

Ecosystems may exist in alternative stable states and thereby extremely differ in ecosystem structure and functions, including gross primary productivity (GPP), which is crucial for assessing an ecosystem’s ability to capture atmospheric carbon dioxide, especially under the context of climate change. This study applied alternative stable states theory to evaluate GPP in global dryland forests, and analyzed multi-year average GPP data alongside environmental factors such as the Aridity Index and mean annual precipitation. Here, we found the existence of alternative stable states of GPP along the aridity gradient. Mean GPP were 893.12 gC/m²/year and 1539.86 gC/m²/year under lower and higher branches of alternative stable states, respectively, compared to the current mean value of 1203.02 gC/m²/year. Notably, we observed striking regional disparities in GPP, with Africa and Oceania predominantly in the higher alternative stable state, while North America and Asia were in the lower alternative stable state. However, GPP along mean annual precipitation did not exhibit alternative stable states, but a significant variation during the medium range of mean annual precipitation (241-402 mm year-1). The relationships between GPP data and environmental factors were consistent across different forest types. This study sheds light on dryland forest productivity and indicates adaptive management strategies that should be used to bolster ecosystem function in the context of climate change.

A document by Behnam Shakiba. Click on the document to view its contents.

not-yet-known not-yet-known not-yet-known unknown Cause analysis and nursing experience of a case of thrombus on Eustachian valve after PICC catheterization Guan-Jun Ye, Qian-Ru Zhu, Yan-Fen Yu, Chun-Ying Wang, Su-Pei Hu, Qin Zhou, Juan He Department of Nursing, No.2 Hospital, Ningbo, Zhejiang, China Address correspondence to: Guan-Jun Ye, Department of Nursing, No.2 Hospital, No. 41 Xibei Street, Ningbo 315000, Zhejiang, China. Tel: (86)-13958229524;E-mail: [email protected] [Abstract] In this article, we have summarized and analyzed the causes and nursing experience of thrombosis on the eustachian valve in the right atrium of a patient with advanced gastric cancer during chemotherapy after PICC insertion. The nursing points included organizing multi-disciplinary joint consultation, vigilance against pulmonary embolism, nursing with anticoagulant drugs, and individualized psychological nursing. Finally, after 22 days of active treatment, the thrombus almost disappeared. [Key words] PICC; Complications; Right atrial thrombus; Eustachian valve; Nursing Care

not-yet-known not-yet-known not-yet-known unknown Pulmonary Mucormycosis in a Patient with Decompensated Cirrhosis of the Liver Successfully Treated with Oral Posaconazole- A Case Report

Four significant influenza outbreaks have occurred over the past 100 years, and the 1918 flu pandemic is the most severe. Since influenza viruses undergo antigenic evolution, they are the pathogens most likely to trigger a new pandemic shortly. Intranasal vaccination offers a promising strategy for preventing diseases triggered by respiratory viruses by eliciting an immunoglobulin A (IgA) response, limiting virus replication and transmission from the respiratory tract more efficiently than intramuscular vaccines. Combining intranasal administration and mRNA-lipid nanoparticles can be an ideal strategy for limiting the extent of the next flu pandemic. This study explored the immunogenicity of intranasally delivered mRNA encapsulated in mannose-histidine-conjugated chitosan lipid nanoparticles (MHCS-LNPs) as a vaccine against influenza A (H1N1) in BALB/c mice. Intranasal administration of mRNA-MHCS-LNPs resulted in the generation of influenza A (H1N1) hemagglutinin-specific neutralizing antibodies in vaccinated animals. The ELISA results indicated a notable increase in the quantity of IgG and IgA antibodies in serum and the Bronchoalveolar Lavage Fluid (BALF), respectively, and exhibited influenza A-specific IFN-γ secretion in vaccinated mice, as well as a noticeable alteration in IL-5 production. Overall, this study demonstrated an effective immunogenic response against respiratory viral infections through intranasal delivery of an mRNA-MHCS-LNP vaccine.

Objectives: The objective of this study was to investigate the impact of acetylcholine signaling pathways on tumor progression, focusing on the activation of nicotinic acetylcholine receptors in breast, prostate, and lung cancer cell lines. Methods: We examined the production and release of acetylcholine in the central nervous system and its potential effects on tumors in the peripheral environment. Utilizing breast, prostate, and lung cancer cell lines, we explored the signaling pathways associated with the activation of nicotinic acetylcholine receptors. Results: Our study revealed insights into the modulation of specific tumor profiling signaling pathways through the activation of nicotinic acetylcholine receptors. We observed notable implications for patient well-being and mortality rates based on the manipulation of these pathways. Conclusion: The findings from this investigation provide valuable information on the intricate relationship between acetylcholine signaling and tumor progression. By elucidating these pathways, there is potential for targeted interventions to enhance patient outcomes and mitigate mortality rates in breast, prostate, and lung cancer cases.

not-yet-known not-yet-known not-yet-known unknown Background: The investigation of cuproptosis in relation to tumor development has been limited, particularly in Multiple myeloma (MM), indicating the need for further research. Our study aimed to examine the impact of cuproptosis-related genes on the prognosis of MM. Methods: Using the datasets, we filtered cuproptosis score-related differentially expressed genes (CRDEGs) by overlapping the DEGs between the MM and normal groups and between the high and low cuproptosis score groups. Additionally, key module genes were identified through weighted gene co-expression network analysis. A univariate Cox algorithm and multivariate Cox analysis were employed to obtain biomarkers of MM and build a prognostic model, before conducting independent prognostic analysis. Results: A total of 59 CRDEGs were filtered. Demonstrating their involvement in the COPII vesicle coat and endoplasmic reticulum protein processing and protein processing in the endoplasmic reticulum. Six prognosis-related biomarkers (PARP1, EDEM3, SEC23A, RSL24D1, TTC37, and SRP72) were obtained, and a prognostic model was developed. The performance of the model was verified using a test cohort (GSE136324 dataset) and a validation cohort (GSE24080 dataset). Risk score, age, albumin, International Staging System (ISS) score, and β2-microglobulin (B2M) was found to be a significant predictor of prognosis independently . Conclusion: As a result of this investigation, a set of six biomarkers associated with cuproptosis (PARP1, EDEM3, SEC23A, RSL24D1, TTC37 and SRP72) were screened to provide a basis for predicting the prognosis of MM.

Purpose： The risk factors fordeath at different intervals (6 months, 6-12 months, and 12-18 months) following TACE in 213 HCC patients were analyzed, leading to the establishment of a prognostic risk model for these patients. Patients and Methods: Liver cancer patients who underwent TACE at Zunyi Medical University between April 2011 and June 2019 were included in the study. Collected clinical data included AFP levels, demographics, tumor characteristics, treatment details, and liver function markers. The study tracked patients from their first admission to their last follow-up or death, with a median follow-up duration of 7.4 months. Logistic and Cox regression analyses were performed to evaluate death at different post-surgery intervals, and survival differences were assessed using the Kaplan-Meier method. A prognostic nomogram was developed and validated using the C-index, ROC curves, and calibration curves to assess model performance. Results： At the end of the follow-up, 39 out of 213 patients survived, while 174 had died, with a median survival time of 6 months. Logistic regression analysis identified AST/ALT > 1 and HBV positivity as risk factors for death within 6 months post-TACE, Child-Pugh grade B at 6-12 months, and multiple tumors at 12-18 months. Cox regression analysis showed that portal vein thrombosis, multiple tumors, tumors in both liver lobes, distant metastasis, elevated white blood cell and neutrophil counts, AST/ALT > 1, low albumin, HBV positivity, Okuda grade II, Child-Pugh grade C, and BCLC grade C were significant factors affecting overall survival (P < 0.05). Key independent risk factors were portal vein thrombosis, AST/ALT > 1, and Child-Pugh grade C, while more than two TACE treatments served as a protective factor. Key independent risk factors were portal vein thrombosis, AST/ALT > 1, and Child-Pugh grade C, while more than two TACE treatments served as a protective factor. Conclusions： Our study identifies high-risk factors for death following TACE, including AST/ALT > 1, HBV positivity, Child-Pugh class B, and multiple tumors at different time intervals. A 13-variable nomogram was developed, demonstrating strong predictive ability and potential for clinical application to enhance patient prognosis and survival.

Background Data are scarce regarding WPW syndrome and asymptomatic pre-excitation in Africa. Objectives This study aimed to understand how accessory pathways related arrhythmias are managed in Africa. Methods This prospective study was conducted in 20 centers from 17 African countries. All the included participants had ventricular pre-excitation patterns. The data collected included symptoms, locations of accessory pathways (AP) and tachyarrhythmia, risk stratification, as well as acute and long-term management. In addition, we assessed the clinical effectiveness and the impact of socio-economic and health metrics on this treatment approach. Results Of 541 participants, 93% were diagnosed with WPW syndrome, and orthodromic atrioventricular reciprocating tachycardia (AVRT) was the most prevalent arrhythmia, affecting 55% of the cases. Approximately 30% of patients, excluding the southern region, received Intravenous Amiodarone as the first-choice drug for orthodromic AVRT while Adenosine was the drug of choice in Southern region. Electrical cardioversion was the first-line treatment for pre-excited atrial fibrillation and antidromic AVRT across all of Africa. Radiofrequency ablation was the first long-term therapy option for 88 % of patients in all African regions, except in western and central Africa, where it was implemented for less than 30% of patients (P<0.001). The rates of success, long-term recurrence, and complication were 93%, 4.1%, and 3.8%, respectively. Conclusion Significant differences and challenges in the diagnosis and management strategies among countries are reported across Africa. While several countries fell short of ideal or expected health expenditures, ablation techniques are rising with success rates comparable to those in the developed world.