• GISS-E2.1 accurately simulates variations of precipitation 𝛿 18 O and d-excess but slightly underestimates d-excess values at low latitudes. • GISS-E2.1 overestimates 17 O-excess in polar regions, possibly due to inaccuracy in representing the supersaturation effect. • In tropical regions, the spatiotemporal distributions of d-excess and 17 O-excess are sensitive to rain evaporation.