Aims: To explore the relationship between non-high-density to high-density lipoprotein cholesterol ratio (NHHR) and nephrolithiasis incidence among United State adult men and women. Methods: Data was obtained from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) which examined a non-pregnant cohort, ≥20 years of age, with adequate NHHR index and nephrolithiasis information. We employed subgroup assessment and weighted uni- and multivariate logistic regression models to determine the distinct link between NHHR and nephrolithiasis risk. Results: In all, 30969 subjects were recruited for analysis, with 9.97% nephrolithiasis and 2.92±0.02 mean NHHR value. Nephrolithiasis incidence increased with higher quartiles of NHHR. After fully adjusting the covariates, participants with the largest NHHR quartiles exhibited a 34% (OR: 1.34, 95%CI: 1.04–1.72, P = 0.02) raised nephrolithiasis risk, relative to participants with least NHHR quartiles. Based on the two-piece-wise regression, the breakpoint was NHHR = 3.53, and a positive association was more evident when NHHR < 3.53 (OR = 1.22, 95%CI: 1.08–1.37, P = 0.002). When NHHR ≥ 3.53, the correlation disappeared (P = 0.14). Using subgroup and interaction analysis, we reveled a strong association between NHHR and nephrolithiasis. This association was consistent across different population environments, except for a significant interaction effect of smoking status on NHHR.

Aims: The primary objective was an evaluation of the correlation between the lymphocyte-to-C-reactive protein ratio (LCR) and the prevalence of overactive bladder (OAB) within the adult United States population. Methods: Data was collected from the National Health and Nutrition Examination Survey (2005‒2010), and involved a non-pregnant cohort aged ≥20 years of age, with available LCR index and OAB information. We employed weighted univariate and multivariate logistic regression to assess the link between LCR and OAB risk. Subgroup, examinations of interaction, and restricted cubic spline analyses were also performed. Results: In all, 13723 subjects were recruited for analysis. Among them, 14.99% exhibited OAB and the mean LCR value was 2.61±0.07. The OAB risk decreased with higher quartiles of LCR. In model 2, subjects in the highest LCR quartiles showed 48% (OR: 0.52, 95%CI: 0.38–0.71, P < 0.001) reductions in the OAB risk, relative to those in the lowest LCR quartiles. These negative associations were found to be independent of various factors, shown in the subgroup analyses and interaction tests. Additionally, based on the restricted cubic spline analyses, there was a negative, non-linear relationship between LCR and OAB risk.