The anti-IgE autoantibodies are biomarkers of early omalizumab response in patients with chronic spontaneous urticariaYusuke Niwa1,2), Koremasa Hayama1,2)*, Shota Toyoshima3), Keisuke Shimizu1,2), Maho Tagui1,2), Mana Ito1,2), Tomomi Sakamoto2), Tadashi Terui1,2), Hideki Fujita1,2), Yoshimichi Okayama2,4,5,6,7)*1) Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, Tokyo, Japan2) Center for Allergy, Nihon University School of Medicine, Tokyo, Japan3) Department of Biochemistry & Molecular Biology, Nippon Medical School, Tokyo, Japan4) Department of Allergy, Internal Medicine, Misato Kenwa Hospital, Saitama, Japan5) Department of Medicine, Division of Respiratory Medicine, Nihon University School of Medicine, Tokyo, Japan6) Department of Internal Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Tokyo, Japan7) Advanced Medical Science Research Center, Gunma Paz University, Graduate School of Health Sciences, Gunma, Japan*Corresponding authors:Koremasa Hayama, M.D, Ph.D.Division of Cutaneous Science, Department of Dermatology, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, JapanTel.: +81-3-3972-8111 (Ext. 8144): Fax: +81-3-5995-9841E-mail: [email protected] Okayama, M.D, Ph.D.Department of Allergy, Internal Medicine, Misato Kenwa Hospital, 4-491-1 Takano, Misato-shi, Saitama 341-8555, JapanTel.: +81-48-955-7171: Fax: +81-48-955-5120E-mail: [email protected]