Using the Weather Research and Forecasting (WRF) model with two planetary boundary layer schemes, ACM2 and MYNN, convection-permitting model (CPM) regional climate simulations were conducted for a 6-year period at a 15-km grid spacing covering entire South America and a nested convection-permitting 3-km grid spacing covering the Peruvian central Andes region. These two CPM simulations along with a 4-km simulation covering South America produced by National Center for Atmospheric Research, three gridded global precipitation datasets, and rain gauge data in Peru and Brazil, are used to document the characteristics of precipitation and MCSs in the Peruvian central Andes region. Results show that all km-scale simulations generally capture the spatiotemporal patterns of precipitation and MCSs at both seasonal and diurnal scales, although biases exist in aspects such as precipitation intensity and MCS frequency, size, propagation speed, and associated precipitation intensity. The 3-km simulation using MYNN scheme generally outperforms the other simulations in capturing seasonal and diurnal precipitation over the mountain, while both it and the 4-km simulation demonstrate superior performance in the western Amazon Basin, based on the comparison to the gridded precipitation products and gauge data. Dynamic factors, primarily low-level jet and terrain-induced uplift, are the key drivers for precipitation and MCS genesis along the east slope of the Andes, while thermodynamic factors control the precipitation and MCS activity in the western Amazon Basin and over elevated mountainous regions. The study suggests aspects of the model needing improvement and the choice of better model configurations for future regional climate projections.