Background: There is a growing body of data to support the presence of sex disparities in outcomes of cardiovascular related hospitalizations. Despite this, there remains a paucity of data on relationships between sex and in-hospital outcomes in patients receiving a left atrial appendage occlusion device (LAAOD). Methods: We examined the 2016-2020 Nationwide Readmission Database to identify patients with Atrial Fibrillation receiving a LAAOD. Men were used as our control group, while women comprised our cohort. The primary outcome was inpatient mortality. Secondary outcomes included odds of mechanical ventilation use, all cause 30-day readmission, cardiogenic shock, pericardial complications, length of stay (LOS) and total hospitalization charges (THC). Multivariate linear and logistic regression models were used to adjust for confounders. Results: Among the patients with Atrial fibrillation receiving LAAOD (N = 59,655), 43% were Female. A Female sex was associated with higher odds of inpatient mortality (adjusted OR [aOR] 1.92, 95% CI 1.04 – 3.5), cardiogenic shock (aOR 4.07, 95% CI 1.82 – 9.1), mechanical ventilation use (aOR 2.02, 95% CI 1.4 – 2.9), all cause 30-day readmission (aOR 1.33, 95% CI 1.22 – 1.45), pericardial complications (aOR 2.5, 95% CI 1.83 – 3.3), longer LOS (1.34 vs 1.19 days, p<0.001) and lower THC ($116,330 vs. $121,1870, p<0.001) compared to male patients receiving a LAAOD. Conclusion: Among patients with Atrial Fibrillation receiving a LAAOD, a female sex was associated with higher odds of mortality, non-fatal adverse events, and lower resource utilization compared to male patients.

Background Balloon Tipped Temporary Pacemakers (BTTP) are the most used temporary pacemakers; however, they are associated with a risk of dislodgement and thromboembolism. Recently, Temporary Permanent Pacemakers (TPPM) have become increasingly used. Evidence of better outcomes with TPPM compared to BTTP is still scarce. Materials and methods Retrospective, chart review study evaluating all patients who underwent temporary pacemaker placement between 2014 and 2022 (N=126) in the cardiac catheterization laboratory (CCL) at a level 1 trauma center. Primary outcome of this study is to evaluate the safety profile of TPPM vs BTTP. Secondary objectives include patient ambulation and healthcare utilization in patients with temporary pacemakers. Results Both groups had similar baseline characteristics distribution including gender, race and age at temporary pacemaker insertion (p>0.05). Subclavian vein was the most common site of access for the TPPM cohort (89.0%) vs the femoral vein in the BTTP group (65.1%). Ambulation was only possible in the TPPM group (55.6%, p<0.001). Lead dislodgement, venous thromboembolism, local hematoma, and access site infections were less frequently encountered in the TPPM group (OR = 0.23 [95% CI (0.10-0.67), P<0.001]). Within the subgroup of patients with TPPM, 36.6% of the patients were monitored outside the ICU setting. There was no significant difference in the pacemaker related adverse events among patients with TPPM based on their in-hospital setting. Conclusion TPPM are associated with more favorable safety profile compared to BTTP. They are also associated with earlier patient ambulation and reduced healthcare utilization.