Objective: To evaluate the implementation of the London Measure of Unplanned Pregnancy (LMUP) in antenatal care. Design: Mixed methods evaluation of a pilot. Setting: Antenatal care at University College London Hospital and Homerton Hospital, England, 2019-2022. Population: Pregnant women attending antenatal care at one of the sites during the evaluation. Methods: Quantitative and psychometric analysis of anonymous data and qualitative analysis of interviews and focus groups with women and midwives, using a Framework Analysis. Main Outcome Measures: Acceptability of the inclusion of the LMUP, measured by completion rates and women’s and midwives opinions. Results: Completion of the LMUP at UCLH stabilised at around 70% and the LMUP performed as expected. Asking the LMUP at antenatal booking appointments is feasible and acceptable to women and midwives. Advantages of asking the LMUP, highlighted by participants, include providing additional support and personalising care. Midwives’ concerns about judgment were unsubstantiated; women with unplanned pregnancies valued such discussions. Conclusions: These findings support the implementation of the LMUP in routine antenatal care and show how it can provide valuable insights into the circumstances of women’s pregnancies. This can be used to help midwives personalise care, and potentially reduce adverse outcomes and subsequent unplanned pregnancy. Integration of the LMUP into the Maternity Services Data Set, will establish national data collection for a population-level measure of unplanned pregnancy, serving as a key outcome measure for sexual and reproductive health and enabling analysis of the prevalence, factors, and implications of unplanned pregnancies across subpopulations to inform implementation. Funding : NIHR PDF-2017-10-021

Background: Maternal folic acid supplementation is protective against the development of neural tube defects (NTDs) in babies. However, recent public-facing communications have raised concerns about a causal relationship between folic acid supplementation, particularly after the first trimester, and ankyloglossia (tongue-tie) in infants. Non-evidence-based communications are potentially harmful because they could adversely affect adherence to folic acid supplementation, increasing NTD occurrence. Objectives: To review evidence on the relationships between maternal folic acid supplementation during preconception and/or pregnancy and the risk of ankyloglossia in infants. Search Strategy: We searched online bibliographic databases for studies investigating the effect of maternal folic acid supplementation during preconception or pregnancy on the occurrence of ankyloglossia in offspring. Selection Criteria: Observational, interventional studies, and systematic reviews assessing the relationships between folic acid and ankyloglossia. Data Collection and Analysis: The database searches yielded 93 articles. After removing duplicates and screening titles and abstracts, 26 remained. One article was judged relevant for inclusion in analyses; a case-control study that directly mentions the relationship between folic acid supplementation and ankyloglossia Main Results: One case-control study reported that regular intake of folic acid supplements was higher in women with infants with ankyloglossia. However, this study has limitations regarding design, selection bias, and confounding, calling the findings into question. Conclusions: Insufficient evidence exists for a relationship between folic acid supplementation and ankyloglossia. Currently, the benefits of folic acid supplementation far outweigh the risks. This must be clearly communicated to patients by their clinicians during preconception and antenatal care.