In modern power systems, the impact of random power sources and loads on power systems is increasing, resulting in threatened system frequency security. However, traditional methods are often not comprehensive in modelling randomness, and there is no analytical method to assess the frequency response of power systems under uncertain power disturbances. In this paper, the power disturbance in a power system is regarded as an interval random quantity. Based on a general model of the system frequency response (SFR-G) and the theory of stochastic processes, an analytical prediction method of the power system frequency deviation under uncertain power disturbance is proposed. Through further deduction, the allowable range of power disturbance under the premise of secure frequency deviation can also be defined, which provides a reference for frequency security and accident prevention in power systems. Numerical simulations demonstrate that the proposed analytical method can delimit the response interval of system frequency deviation well, and the backstepping calculation can also delimit the allowable range of power disturbance to ensure the secure operation of the system.