The diversity of slip processes occurring in the megathrust indicates that stress is highly variable in space and time. Based on GNSS and InSAR data, we study in depth the evolution of the interplate slip-rate along the Oaxaca subduction zone, Mexico, from October 2016 through August 2020, including the pre-seismic, coseismic and post-seismic phases associated with the 2020 Mw 7.4 Huatulco earthquake, to understand how different slip processes contribute to the stress accumulation in the region. Our results show that continuous changes in both the aseismic stress-releasing slip and the coupling produced a high stress concentration over the main asperity of the Huatulco earthquake and a stress shadow zone in the adjacent updip region. These findings may explain both the downdip rupture propagation of the Huatulco earthquake and its rupture impediment to shallower, tsunamigenic interface regions, respectively. Time variations of the interplate coupling around the adjacent 1978 Puerto Escondido rupture zone clearly correlate with the occurrence of the last three Slow Slip Events (SSEs) in Oaxaca far downdip of this zone, suggesting that SSEs are systematically accompanied by interplate coupling counterparts in the shallower seismogenic zone. In the same period, the interface region of the 1978 event experienced a remarkably high CFS built-up, imparted by the co-seismic and early post-seismic slip of the Huatulco rupture, indicating large earthquake potential near Puerto Escondido. Continuous monitoring of the interplate slip-rate thus provides a better estimation of the stress accumulation in the seismogenic regions where future earthquakes are likely to occur.