The One Health concept provides a framework to examine the linkages between human, animal, plant, environmental, and ecosystem health. This framework can be represented as a multi-dimensional matrix tool that can be used to examine and address complex GeoHealth challenges. This matrix tool facilitates comprehensive, systems-based thinking and can include up to four dimensions depending upon users' needs. This presentation will briefly review the One Health matrix tool and apply it, as an example, to examine the global impact of human and animal fecal wastes. Applying the tool reveals linkages between food-borne illnesses, food insecurity, antimicrobial resistance, and climate change. Understanding these linkages is necessary for developing effective and equitable public policies that are needed to achieve many of the United Nations' Sustainable Development Goals.