Deinococcus radiodurans has been reported to show remarkable resistance to ionizing radiation, desiccation, oxidizing compounds, UV radiation and mutagens. Since the 1960s, several exposure tests on diverse bacteria in space have been conducted to study the possibility of interplanetary life transfer and this bacterium pertains to a distinct gram-negative eubacterial lineage that is considered to be most closely related to the genus Thermus. The chemical reaction of D. radiodurans after exposure to space-related radiation and vacuum was studied in the concerned research that extends the application of the Tanpopo mission conducted by Japan. Certain tests like Scanning electron microscopy demonstrated that irradiated cell shape and cellular integrity were unaffected, whereas combined proteome and metabolomic research revealed significant molecular modifications in metabolic and stress response pathways. Taking this into account reinforced with simulation studies, we propose fabrication of a wearable radiation-shielding bio-spacesuit to protect the astronauts and prevent the onset of acute radiation damage. The main focus of this study is on the idea of incorporating the organism's composition mechanisms either into the five layers of mylar or aerogel of spacesuit in order to prevent damaging radiation in space.