The eruption of the submarine Hunga volcano in January 2022 was associated with a powerful blast that injected volcanic material to altitudes up to 58 km. From a combination of various types of satellite and ground-based observations supported by transport modeling, we show evidence for an unprecedented increase in the global stratospheric water mass by 13% as compared to climatological levels, and a 5-fold increase of stratospheric aerosol load, the highest in the last three decades. Owing to the extreme injection altitude, the volcanic plume has circumnavigated the Earth in only one week and dispersed nearly pole-to-pole in three months. The unique nature and magnitude of the global stratospheric perturbation by the Hunga eruption ranks it among the most remarkable climatic events in the modern observation era, with a range of potential persistent repercussions for stratospheric composition and climate.