In deglaciating environments, rock mass weakening and potential formation of rock slope instabilities is driven by long-term and seasonal changes in thermal- and hydraulic boundary conditions, combined with unloading due to ice melting. However, in-situ observations are rare. In this study, we present new monitoring data from three highly instrumented boreholes, and numerical simulations to investigate rock slope temperature evolution and micrometer-scale deformation during deglaciation. Our results show that the subsurface temperatures are adjusting to a new, warmer surface temperature following ice retreat. Heat conduction is identified as the dominant heat transfer process at sites with intact rock. Observed non-conductive processes are related to groundwater exchange with cold subglacial water, snowmelt infiltration, or creek water infiltration. Our strain data shows that annual surface temperature cycles cause thermoelastic deformation that dominate the strain signals in the shallow thermally active layer at our stable rock slope locations. At deeper sensors, reversible strain signals correlating with pore pressure fluctuations dominate. Irreversible deformation, which we relate with progressive rock mass damage, occurs as short-term (hours to weeks) strain events and as slower, continuous strain trends. The majority of the short-term irreversible strain events coincides with precipitation events or pore pressure changes. Longer-term trends in the strain time series and a minority of short-term strain events cannot directly be related to any of the investigated drivers. We propose that the observed increased damage accumulation close to the glacier margin can significantly contribute to the long-term formation of paraglacial rock slope instabilities during multiple glacial cycles.