Louisiana is among the most vulnerable places on Earth to coastal flooding, for many reasons. Tropical-cyclone-induced storm surge, shoreline erosion accelerated by eustatic sea level rise, tidal influences, minimization of river sediment nourishment due to the presence of levees, and land subsidence caused by compaction of marsh lands and underground resource extraction all contribute to the flood hazard. In addition, increasing frequency and intensity of natural hazards under climate change scenarios are expected to exacerbate the coastal flood risk. Many studies focus on flood risk assessment and mitigation strategies both for the present and future, and other research has analyzed future flood risk considering climate change and sea level rise. Yet few studies consider all of these factors in concert. This research represents a comprehensive approach that considers coastal subsidence, eustatic sea level rise, and tropical cyclone storm surge variability under climate change scenarios, to evaluate future flood risk at the individual building level in Grand Isle, Louisiana. Results suggest that on average, the 100-year flood depth will increase by 37 cm at the individual building level in Grand Isle by 2050, with subsidence contributing over 80 percent of this increase. Subsidence is projected to increase structure and content losses by approximately 18 percent above modeled losses at present, while eustatic sea level rise may contribute approximately one percent of additional losses. A 100-year storm surge event amid a “low” scenario of environmental change would increase the structure and content losses at Grand Isle by 68–74 percent of today’s value in ten years, 141–149 percent in 25 years, and 346–359 percent in 50 years. Even more menacingly, “high” scenarios of environmental change are expected to increase the 100-year storm surge losses by approximately 85–91 percent of today’s value in ten years, 199–218 percent in 25 years, and 407–415 percent in 50 years. Outcomes from this study will fill the gap in the current literature by implementing a more realistic risk assessment model and will direct flood risk managers, property owners, and other stakeholders to build a comprehensive framework to minimize future flood risk in one of the most vulnerable sites in the USA to coastal flooding.