The study was aimed to identify the relations between the severity of coronary artery disease and associated percutaneous coronary interventions with the changes in the local Earth magnetic field activity (LEMF). One-thousand-two-hundred-forty patients diagnosed with Acute coronary syndrome who underwent percutaneous coronary intervention within 2015-2016 were retrospectively included in this single centre study. The majority of acute coronary syndromes that occurred in females was associated with an increase in LEMF intensity in 3.5-32 Hz frequency ranges and were also associated with a higher number of diseased coronary arteries. Increased intensity in the same range was associated with a lower number of stented coronary arteries in males in 2015. Positive correlation coefficients were found between increased LEMF intensity in the 0-15 Hz range and the number of revascularized coronary arteries in females during the winter season in 2016. Stronger LEMF in low-medium frequency ranges is associated with acute coronary syndromes in males caused by less diffuse coronary artery disease resulting in lower number of coronary arteries segments needed for revascularisation, especially during winter. Stronger LEMF in high frequency range is associated with increased occurrence of ischaemic cardiovascular events, while stronger LEMF in low to moderate frequency ranges is associated with positive effect.