Kaposi's sarcoma is a common cancer associated with HIV infection. Since the COVID-19 pandemic, the prevalence of this pathology has increased. We report a case of a 33-year-old patient who presented with Kaposi's sarcoma associated with Covid-19 and HIV coinfection. It promotes the progression of cancers and increases mortality.

Mandibular osteosarcomas are relatively rare compared to those occurring in the long bones. We report a case of giant mandibular osteosarcoma in a 52-year-old woman that we realized a complete resection. An early diagnosis and a complete resection of the lesion are necessary for a better prognosis.