Introduction:Folic acid deficiency is an important nutritional concern characterized by decreased levels of folate in the body, leading to different health consequences including megaloblastic anemia and neurological deficits [1]. The metabolism of folate is associated with different physiological processes, including DNA synthesis and cell division, highlighting its significant role in maintaining overall health [2]. Hypothyroidism, a prevalent endocrine disorder resulting from lack of thyroid hormone synthesis, affects millions around the world and presents with a wide range of clinical symptoms [3]. While the link between thyroid insufficient and decreased folate metabolism has been described in literature, there remains a lack of detailed findings specially reporting folic acid deficiency induced by severe hypothyroidism or vice versa. This case report seeks to bridge this gap by presenting a clinical case and reviewing relevant literature to enhance our understanding of this rare known comorbidity.The importance of investigating folic acid deficiency in the connection of severe hypothyroidism lies in its possibly clinical significance. Due to the universal prevalence of both hypothyroidism and folic acid deficiency, understanding their co-operation could contribute valuable understanding into enhancing patient outcomes and guiding clinical intervention settings. Moreover, explaining the mechanisms which is the foundation of this dual deficiency may inform future research endeavors aimed at developing targeted interventions and preventive measures. Furthermore, by inducing vigilant behavior of this underreported comorbidity, physicians can improve their diagnostic acumen and contribute more complete care to the affected individuals experiencing the symptoms insinuating both of the illnesses. In this case report, we present a case of 22-year- old woman who presented with folic acid deficiency anemia and hypothyroidism.
