We report a 24-year-old female patient with a neurological deficit without fever or meningeal syndrome. HIV serology was negative and CD4 count was normal. Cerebrospinal fluid analysis revealed the presence of Cryptococcus neoformans. Neuromeningeal cryptococcosis was suspected. The initial course was favourable with antifungal therapy.

Rendu Osler's disease is a genetic disease characterized by mucocutaneous and visceral telangiectasias. Rendu Osler's disease was discovered during hypoxemia during an outbreak of SARS-Cov2.This was a 36-year-old woman with exertional dyspnea and severe hypoxemia revealing pulmonary arteriovenous malformations on chest CT scan.