Cost-effectiveness of an app-based treatment for urinary incontinence in
comparison to care as usual in general practice: A pragmatic randomised
controlled trial over 12 months
Abstract
Objective: Long-term cost-effectiveness of app-based treatment for
female stress, urgency, or mixed urinary incontinence (UI) compared to
care-as-usual in primary care. Design: A pragmatic, randomised
controlled, superiority trial. Setting: Primary care in the Netherlands
from 2015 to 2018, follow-up at 12 months. Population: Women with ≥2
UI-episodes per week, access to mobile apps, wanting treatment. 262
women randomised equally to app or care-as-usual; 89 (68%) and 83
(63%) attended follow-up. Methods: The standalone app included
conservative management for UI with motivation aids (e.g., reminders).
Care-as-usual delivered according to the Dutch GP guideline for UI. Main
outcome measures: Effectiveness assessed by the change in symptom
severity score (ICIQ-UI-SF) and the change in quality of life
(ICIQ-LUTS-QoL, EQ-5D-5L) on superiority with linear regression on an
intention-to-treat basis. Cost-effectiveness and -utility from a
societal perspective, based on Incontinence Impact Adjusted Life Years
(IIALYs) and Quality Adjusted Life years (QALYs). Results: Clinically
relevant improvement of UI severity for both app (-2.17 ± 2.81) and
care-as-usual (-3.43 ± 3.6), with a non-significant mean difference of
0.903 (-0.66 to 1.871). Costs were lower for app-based treatment with
\euro-161 (95%CI: -180 to -151) per year. Cost-effectiveness showed
small mean differences in effect for IIALY (0.04) and QALY (-0.03) and
thus larger ICER (-3,696) and ICUR (\euro6,379). Conclusion: App-based
treatment is a viable alternative to care-as-usual for UI in primary
care in terms of long-term cost-effectiveness. Funding: Dutch
Organisation for Health Research and Development (ZonMw: 837001508),
sub-funding P.W. Boer Foundation Dutch Trial Register identifier: Trial
NL4948 (www.trialregister.nl/trial/4948).