Aims: To determine the prevalence of depression and anxiety in Indian patients undergoing CABG surgery and their relationship to physical activity and quality of life. Methods: 121 patients undergoing CABG surgery between November 2017 and May 2019 were included. The Hospital Anxiety and Depression Scale (HADS) was employed for the assessment of depression and anxiety. Health-related quality of life was assessed using the SF-36 questionnaire. The short form of the International Physical Activity Questionnaire (IPAQ) was used for assessment of physical activity. Participants were categorized into high, moderate or low physical activity. Results: The overall prevalence (95% CI) of depression and anxiety was 70.5% (0.61-0.78) and 64.6% (0.55-0.73) respectively. When a cut-off score of 11 instead of 8 was used on the HADS [Borderline cases excluded (HADS score 8-10)], the prevalence of depression and anxiety was 31.3% (0.22-0.40) and 40.7% (0.31-0.50) respectively. Patients with low levels of physical activity had a higher prevalence of depression and anxiety (p < 0.05). Patients with depression demonstrated a worse quality of life compared to those without depression in all domains measured by the SF-36 questionnaire. Among patients with anxiety, quality of life was worse in four out of the eight domains measured by the SF-36 questionnaire. Conclusion: Indian patients undergoing CABG surgery have a high prevalence of depression and anxiety. Patients with depression and anxiety were found to have low physical activity and poor quality of life when compared to their counterpart. Keywords: CABG; depression; anxiety; quality of life; physical activity.