Pulmonary hypertension (PH) is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increase in pulmonary artery pressure, which eventually develops to right heart failure and death. Though newly discovered and incredible treatment strategies in recent years have improved the prognosis of PH, the fact that limited types of effective and economical drugs for PH is available still makes it as a life-threatening disease. Some drugs from Chinese Materia Medica are traditionally applied in treating lung diseases. Accumulating evidence suggests the active pharmaceutical ingredients (APIs) derived from those medicines have brought prospective future for prevention and treatment of PH. In this review, we summarized the pharmacological effects of APIs derived from CMM which is potent in treating PH, aiming at bringing new ideas in initial drug discovery and identification of potential therapeutic strategies in alternative medicine for PH.