not-yet-known not-yet-known not-yet-known unknown Background: Allergic bronchopulmonary aspergillosis (ABPA), which is one of the respiratory complications of cystic fibrosis, is a hypersensitivity reaction in the lung against the antigens of the fungus Aspergillus fumigatus ( A.fumigatus). If left untreated, it may cause irreversible deteriorations in lung functions. The aim of this study is to determine the incidence of ABPA, according to years and to determine the risk factors leading to the development of ABPA by using the CF Registry System of Turkey data. Methods: The study was designed as a retrospective cohort study. Using the CF Registry System of Turkey data, the incidence of ABPA was determined and the data of 44 patients newly diagnosed with ABPA in 2022 and 132 patients with similar mutation weight and age range without ABPA diagnosis in that year were compared, and the risk factors affecting the development of ABPA were determined. Results: Low pulmonary function test values, having had at least one pulmonary exacerbation in that year and receiving intravenous antibiotic treatment, using inhaled antibiotics, having a high number of pulmonary exacerbations, having Pseudomonas aeroginosa (P.aeroginosa) colonization, having a low body mass index (BMI) and having cystic fibrosis related diabetes mellitus (CFRD) were found to be among the risk factors for the development of ABPA. Conclusions: Early recognition and treatment of ABPA is essential to prevent further damage to the lungs. Patients with frequent pulmonary exacerbations, low BMI and low pulmonary function test values, chronic colonization should definitely be considered for ABPA.

Background: The addition of baked-milk products to the diet appears to markedly accelerate the development of tolerance to unheated-milk compared to a strict avoidance diet. Objective: The present study aims to investigate the predictors of baked milk tolerance in children with IgE-mediated cow’s milk allergy. Methods: The study included 80 cases who were diagnosed with IgE-mediated cow’s milk allergy upon oral food challenge (OFC) testing in our clinic. Cases who did and did not develop reactions during OFC with baked milk were compared regarding clinical and laboratory parameters. Results: The cases with cow’s milk allergy were 48 male and 32 female and the average age was 7.25 ± 2.45 (3-13) months. We found that 62.5% of cases showed tolerance to baked milk in the OFC test performed with cakes containing 2.6 g milk protein. When the patients who could and could not tolerate baked milk products were compared as for test results, we detected a statistically significant difference intergroup regarding diameter of wheal in skin prick test (SPT) performed with muffin slurry, levels of sIgE for cow’s milk (CM), sheep’s milk (SM), goat’s milk (GM), casein, and the amount of unheated milk consumed until a reaction developed in the OFC test performed with unheated milk (p <0.05). Conclusion: We defined novel decision points based on for CM, SM, GM, casein sIgE levels, wheal diameter in SPT with muffin slurry, and the amount of milk ingested during OFC performed with unheated milk that may be useful in predicting outcomes to baked milk challenges.