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The association between reproductive outcomes and serum uric acid in women with polycystic ovary syndrome undergoing freeze-all embryo transfer after assisted reproductive technology: a cohort study
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  • Jie Wang,
  • Xinrong Zhou,
  • Jin Liu,
  • Yuan Zhang,
  • Yi Qian,
  • Wei Wu,
  • Chun Yuan,
  • Jing Wang,
  • Xiang Ma
Jie Wang
The First Affiliated Hospital With Nanjing Medical University
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Xinrong Zhou
The First Affiliated Hospital With Nanjing Medical University
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Jin Liu
The First Affiliated Hospital With Nanjing Medical University
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Yuan Zhang
The First Affiliated Hospital With Nanjing Medical University
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Yi Qian
The First Affiliated Hospital With Nanjing Medical University
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Wei Wu
The First Affiliated Hospital With Nanjing Medical University
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Chun Yuan
The First Affiliated Hospital With Nanjing Medical University
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Jing Wang
The First Affiliated Hospital With Nanjing Medical University
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Xiang Ma
The First Affiliated Hospital With Nanjing Medical University

Corresponding Author:[email protected]

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Abstract

OBJECTIVE: To investigate how serum uric acid (SUA) influences the reproductive outcomes among women with polycystic ovary syndrome (PCOS) undergoing freeze-all strategy. DESIGN: Retrospective cohort study. Setting: Reproductive center in a tertiary hospital in China. Population: 1115 women aged 20-40 years with PCOS were included. Method: The entire population was categorized into four groups based on SUA quartiles, logistic regression analysis was conducted to determine odds ratios (ORs) for reproductive and pregnancy complications, adjusting for potential confounders. Main Outcome Measures: Primary outcome was live birth, defined as the gestational age ≥28 weeks or weighing ≥ 1000 grams. RESULTS: In quartiles of SUA levels, there was no significant difference in the live birth rate from the lowest quartile (Q1: 57.9%) to the highest (Q4: 56.6%) (adjusted OR 1.08, 95% CI, 0.74-1.57, P=0.58). Similarly, SUA showed no significant effect on biochemical and clinical pregnancy rate, or miscarriage rate (p>0.05). Women in quartile 4 had added the risk of gestational diabetes mellitus (GDM) (adjusted OR 3.87, 95% CI 1.77-8.47), gestational hypertension (GH) (adjusted OR 3.82, 95% CI 1.16-12.58) compared with quartile 1. Women in quartile 4 also had an increased probability of preterm birth and low birth weight(adjusted OR 2.24, 95% CI 0.90-5.59;adjusted OR 3.58, 95% CI 0.88-14.56, respectively). CONCLUSION: No significant correlation was found between SUA and live birth in women with PCOS undergoing freeze-all strategy. However, elevated SUA increased the risk of GH, GDM and tended to increase the risk of preterm labor and LBWI.
19 Aug 2024Submitted to BJOG: An International Journal of Obstetrics and Gynaecology
20 Aug 2024Submission Checks Completed
20 Aug 2024Assigned to Editor
20 Aug 2024Review(s) Completed, Editorial Evaluation Pending
27 Aug 2024Reviewer(s) Assigned