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Magnetic resonance imaging (MRI) and clinical features of Mayer-Rokitansky-Küster–Hauser (MRKH) syndrome: a 10-year review from a dedicated specialist centre
  • +7
  • Nina Cooper,
  • Maya Al-memar,
  • Kristofer Linton-Reid,
  • Keith Edmonds,
  • Gillian Rose,
  • Nuala Dixon,
  • Cillian McNamara,
  • Christina Fotopoulou,
  • Katherine Van Ree,
  • Nishat Bharwani
Nina Cooper
Imperial College Healthcare NHS Trust

Corresponding Author:[email protected]

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Maya Al-memar
Imperial College Healthcare NHS Trust
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Kristofer Linton-Reid
Imperial College London Department of Surgery and Cancer
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Keith Edmonds
Imperial College Healthcare NHS Trust
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Gillian Rose
Imperial College Healthcare NHS Trust
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Nuala Dixon
Imperial College Healthcare NHS Trust
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Cillian McNamara
Imperial College Healthcare NHS Trust
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Christina Fotopoulou
Imperial College Healthcare NHS Trust
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Katherine Van Ree
Imperial College Healthcare NHS Trust
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Nishat Bharwani
Imperial College Healthcare NHS Trust
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Abstract

Objective: to correlate the clinical history with imaging findings of women with MRKH Design: Retrospective cohort study Setting: A UK IOTA and ESGO-certified tertiary referral centre for disorders of reproductive development Population: All patients with a diagnosis of MRKH and had undergone an MRI pelvis between 1st January 2011 – 31st April 2021 were included Method: MRI images were analysed by specialist gynaecological radiologists. Clinical data was extracted from an electronic patient record system. Statistical analysis was computed in R (version 4.1.2), R base stats package and ggstatsplot (v0.5.0). Outcome measures: clinical history and predefined imaging features Results: 134 patients were included. Median age at MRI was 18 years (10 – 64 years). Half (48.2%) of women presenting had a history of pain, most often abdominal (84.6%) or vaginal (9.2%). Anlage were identified in 91.8% of women (n = 123). 4.5% of women had imaging features of endometriosis (n = 6). Women with a functional anlage were significantly more likely to experience pain (p <0.001). Pain history was not strongly associated with ectopic ovarian position. Common gynaecological pathology such as endometriosis, ovarian cysts and fibroids were also identified. Conclusions: We identify that majority of women with MRKH will have uterine anlage with a connecting fibrous band, and an ectopic ovarian position 44.0% of cases. Abdominal pain was significantly associated with functional anlage on MRI. Further work is required to identify how other gynaecological pathology impacts women with MRKH.
14 Jul 2023Submitted to BJOG: An International Journal of Obstetrics and Gynaecology
14 Jul 2023Submission Checks Completed
14 Jul 2023Assigned to Editor
14 Jul 2023Review(s) Completed, Editorial Evaluation Pending
30 Jul 20241st Revision Received
30 Jul 2024Submission Checks Completed
30 Jul 2024Assigned to Editor
30 Jul 2024Review(s) Completed, Editorial Evaluation Pending
30 Jul 2024Editorial Decision: Accept