1.     Abstract:
Neuroinflammation is involved in several brain neurodegenerative diseases, such as Alzheimer’s Disease (AD) and Multiple Sclerosis (MS)1,2. Horti, A. G. et al. (2019) developed [11C]CPPC, a Positron Emission Tomography (PET) radiotracer with high specificity for the macrophage colony-stimulating factor 1 receptor (CSF1R), essentially expressed in microglia. In addition, the authors discussed [11C]CPPC application in models of neuroinflammation, AD and MS. Here, this commentary will be focused on reviewing the steps for [11C]CPPC radiosynthesis, and discussing its application in animal models of neuroinflammation and a mouse model of AD.
 
2.    Synthesis
The precursor (Pre-CPPC) was prepared in a four-step reaction. Radiosynthesis (Figure 1) of [11C]CPPC was obtained by using [11C]CH3I, with a radiochemical yield of 21 ± 8% and high radiochemical purity (> 95%).