3. Results:
The brain regional distribution of [11C]CPPC was evaluated using healthy C57BL/6J mice. Animals were sacrificed at 5, 15, 30 and 60 min and %SUV calculated.
· Major [11C]CPPC uptake was seen in the frontal cortex with 150% SUV, between 5-15 min after radiotracer injection;
· Blocking studies demonstrated the specific binding of [11C]CPPC only when correcting brain uptake for radioactivity concentration in blood (SUVR);
· Results indicated a 20% decrease on radioactivity in mice treated with high doses of CPPC blocker;
· The [11C]CPPC brain uptake has a small significant reduction in microglia-depleted mice;
The [11C]CPPC brain