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Arrhythmogenicity of monophasic and biphasic PFA waveforms in a porcine model
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  • Hanife Tugba Kumru,
  • Lars Mattison,
  • Khaldoun G. Tarakji,
  • Atul Verma,
  • Daniel C. Sigg
Hanife Tugba Kumru
Medtronic Inc
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Lars Mattison
Medtronic Inc
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Khaldoun G. Tarakji
Medtronic Inc
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Atul Verma
McGill University Health Centre
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Daniel C. Sigg
Medtronic Inc

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Abstract

Objective: The potential risk of inducing ventricular arrhythmias was explored by employing Pulsed Field Ablation (PFA) through the administration of both monophasic and biphasic waveform deliveries. Methods: Pulsed Field Ablation (PFA) was applied to specific locations in the right ventricle (RV, n=5 sites) in swine (n=2), utilizing identical settings with consistent amplitude, pulse width, and number of pulses for both monophasic and biphasic waveforms. PFA deliveries were precisely timed in 10-milisecond intervals across the entire T wave. Results: Using monophasic waveforms, ventricular fibrillation (VF) was induced 7/7 times when PFA pulses were delivered during the T wave. Biphasic waveforms resulted in no ventricular arrhythmias when PFA was delivered across the entire duration of T wave. Conclusions: Our findings indicate that VF can be consistently induced with monophasic pulse waves, but not with biphasic pulse waves in a porcine model.
03 Sep 2024Submitted to Journal of Cardiovascular Electrophysiology
09 Sep 2024Review(s) Completed, Editorial Evaluation Pending
09 Sep 2024Submission Checks Completed
09 Sep 2024Assigned to Editor
10 Sep 2024Reviewer(s) Assigned
19 Sep 2024Editorial Decision: Revise Minor
29 Sep 20241st Revision Received
30 Sep 2024Review(s) Completed, Editorial Evaluation Pending
30 Sep 2024Submission Checks Completed
30 Sep 2024Assigned to Editor
07 Oct 2024Reviewer(s) Assigned
16 Oct 2024Editorial Decision: Accept