Restoration efforts are urgently needed for the conservation of coral reefs. The application of probiotics has recently gained attention due to the positive results in laboratory trials. In situ validation of the beneficial effects of coral probiotics is the natural next step for the development of coral microbiome manipulation research and application. Here, we present the Coral Probiotics Village (CPV) as the first underwater laboratory using an integrated and holistic approach to test innovative solutions to rehabilitate coral reefs, with a main focus on the use of microbial-based therapies. The pillars of this initiative include the establishment of a reproducible platform for sustained environmental data observations, pioneering research, including in situ coral microbiome stewardship, technology development, restoration efforts, disease outbreaks and invasive species surveillance, outreach and education. We also suggest the use of the CPV as a model that can be replicated worldwide.