Assessing Bone Regeneration with T-PRF and L-PRF: A Micro-CT Study
- Nilay ÇALIKOĞLU YAŞAR,
- Gürkan ÜNSAL,
- Hümeyra Arıkan Kocaelli,
- Kaan Orhan,
- Fatma Beyza Sağ
Gürkan ÜNSAL
Western University Schulich School of Medicine & Dentistry
Author ProfileHümeyra Arıkan Kocaelli
Istanbul Universitesi Dis Hekimligi Fakultesi
Author ProfileFatma Beyza Sağ
Istanbul Universitesi Istanbul Tip Fakultesi
Author ProfileAbstract
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Aim/Purpose: This study aims to compare the efficacy of locally applied
Titanium-Platelet Rich Fibrin (T-PRF) and Leukocyte-Platelet Rich Fibrin
(L-PRF) in bone defect healing using micro-CT analysis and
histopathological examination in rabbit models. Materials and Methods:
Eight healthy male New Zealand rabbits, aged 4-6 months, were utilized.
Circular bicortical defects (6 mm diameter) were created at three areas
in each rabbit. One of the defects was chosen as the control group
received saline solution, while T-PRF and L-PRF were applied to the
defect sites in separate experimental groups. Bone regeneration was
analyzed using high-resolution micro-CT and histological evaluation
post-sacrifice. Statistical analysis assessed the significance of
observed differences. Results: Micro-CT analysis revealed significant
differences among the groups in bone volume, trabecular thickness,
trabecular number, connectivity, and connectivity density
(p<0.05). Both T-PRF and L-PRF groups exhibited superior bone
parameters compared to controls, with L-PRF showing higher values.
Trabecular separation and bone surface area to bone volume ratio did not
differ significantly among the groups (p>0.05). Histological
examination indicated advanced healing stages in the L-PRF group,
suggesting both T-PRF and L-PRF contribute to bone regeneration, with
L-PRF demonstrating better effects. Conclusion: The study concludes that
while both T-PRF and L-PRF aid in bone regeneration, L-PRF shows
superior efficacy. L-PRF is recommended for bone defect healing due to
its better performance in enhancing bone parameters.