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High molecular diversity of human adenoviruses in children living in Northwestern Amazon region hospitalized with acute gastroenteritis.
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  • Yan Cardoso Pimenta,
  • Silas de Souza Oliveira,
  • Gabriel Leitão,
  • Laricy da Silva Vieira,
  • Beatriz Vieira da Silva,
  • Flávia Freitas de Oliveira Bonfim,
  • Bruno Loreto de Aragão Pedroso,
  • Alberto Olivares,
  • José Paulo Gagliardi Leite,
  • Lennart Svensson,
  • Johan Nordgren,
  • Marcia Moraes
Yan Cardoso Pimenta
Fundacao Oswaldo Cruz

Corresponding Author:[email protected]

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Silas de Souza Oliveira
Fundacao Oswaldo Cruz
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Gabriel Leitão
Fundacao Oswaldo Cruz Centro de Desenvolvimento Tecnologico em Saude
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Laricy da Silva Vieira
Fundacao Oswaldo Cruz
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Beatriz Vieira da Silva
Fundacao Oswaldo Cruz
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Flávia Freitas de Oliveira Bonfim
Fundacao Oswaldo Cruz
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Bruno Loreto de Aragão Pedroso
Fundacao Oswaldo Cruz
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Alberto Olivares
Universidade Estadual de Roraima
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José Paulo Gagliardi Leite
Fundacao Oswaldo Cruz
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Lennart Svensson
Linkopings universitet Tunnfilmsfysik
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Johan Nordgren
Linkopings universitet Tunnfilmsfysik
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Marcia Moraes
Fundacao Oswaldo Cruz
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Abstract

Objectives: We assessed the prevalence and genetic diversity of human adenovirus in children up to five years old, with and without acute gastroenteritis, in the Amazon region during 2016, 2017, and 2021. Design: This cross-sectional study used fecal samples from children admitted to a hospital in Boa Vista, Roraima. The samples were tested for adenovirus using quantitative real-time PCR and further characterized by PCR and sequencing of three specific genes. Results: Out of 942 samples, 13% tested positive for adenovirus—12% in children with acute gastroenteritis and 15.6% in children without gastroenteritis. Genotyping revealed that species F and C were predominant in acute gastroenteritis cases, while species F and A were more common in non-acute cases. The study found significant temporal variations in prevalence, with the highest rates in 2016. Adenovirus D37 was detected for the first time in Brazil. Conclusions: The study highlighted the notable presence and diversity of adenovirus among children in the Amazon region, emphasizing the need for continuous monitoring.