loading page

Ipratropium-induced bronchospasm in a Chronic Obstructive Pulmonary Disease patient-a rare and serious clinical vignette of altered drug response: a case report
  • +5
  • Arun S,
  • Abhishek Anil,
  • Hariharan Iyer,
  • Jaykaran Charan,
  • Shoban Babu Vartha,
  • Gopal Durgeshwar,
  • Bhavesh Chatwani,
  • Sneha ambwani
Arun S
All India Institute of Medical Sciences - Jodhpur
Author Profile
Abhishek Anil
All India Institute of Medical Sciences - Jodhpur
Author Profile
Hariharan Iyer
All India Institute of Medical Sciences - Jodhpur
Author Profile
Jaykaran Charan
GMERS Medical College and Hospital Department of Pharmacology
Author Profile
Shoban Babu Vartha
All India Institute of Medical Sciences - Jodhpur
Author Profile
Gopal Durgeshwar
All India Institute of Medical Sciences - Jodhpur
Author Profile
Bhavesh Chatwani
All India Institute of Medical Sciences - Jodhpur
Author Profile
Sneha ambwani
All India Institute of Medical Sciences - Jodhpur

Corresponding Author:[email protected]

Author Profile

Abstract

Background: Ipratropium, an anticholinergic medication, holds a significant position in the management of various respiratory disorders. Primarily utilized in the pharmacotherapy of chronic obstructive lung disease and to relieve the symptoms of bronchospasm by acting on the muscarinic receptors of the bronchial smooth muscle by inhibiting the same receptors. This case report aims to highlight the ipratropium-induced bronchospasm in a patient of Chronic Obstructive Pulmonary Disease (COPD). Case Presentation: We present a compelling case of severe bronchospasm occurring in a 65-year-old Indian man following the inhalation of a combination of ipratropium bromide and budesonide. This distressing event was accompanied by a precipitous decline in oxygen saturation, plummeting to as low as 40%. Urgent resuscitation measures were imperative, leading to intubation and ventilatory support to restore the patient to a stable state. Following the initial resuscitation, the patient was transferred to the intensive care unit for further management. Disturbingly, another exacerbation of symptoms ensued during ventilator support subsequent to nebulization with combination of ipratropium and levosalbutamol. Encouragingly, the patient’s condition ameliorated upon discontinuation of the nebulization. Conclusion: This case report illuminates the concerning potential for ipratropium-induced bronchospasm in COPD patients. As we navigate these complexities, the pursuit of safer alternatives like tiotropium takes center stage, reminding us of the continuous evolution in optimizing respiratory therapies. These findings emphasize the significance of vigilant monitoring and tailored interventions in clinical practice.