We are grateful to the authors for sharing the results of this very precise and detailed analysis of the diagnostic performance of apical myocardial perfusion by combining high-frequency linear probe and contrast enhanced ultrasound (CEUS) for the detection of left anterior descending artery (LAD) stenosis. there are many imaging modalities to assess coronary artery stenosis. For example, invasive coronary angiography, coronary computed tomography angiography (CCTA), myocardial nuclear perfusion imaging, cardiac magnetic resonance (CMR)[1], it’s crucial to choose the most appropriate imaging modality for diagnosis, treatment and procedural planning. In previous studies, the quantitative analysis of myocardial perfusion by CEUS were based on 17-segment model to assess the stenosis of the relevant vessels[2], it is relatively cumbersome to perform. Since most of the apical LV is supplied by LAD, the authors quantitative analysis of myocardial blood flow in the apical LV to evaluate the stenosis of the LAD vessels by combining high-frequency linear probe and CEUS, overcoming insufficient near-field resolution and artifacts by the conventional phased-array probe. The authors found that it is feasible and convenient to to assess apical perfusion to reflect LAD stenosis by combining high-frequency linear probe and CEUS with high Area under the curve of β, T, A, and MBF (0.880, 0.881, 0.761, and 0.880 respectively). And the best cut-off of β, T, A, and MBF were 10.32, 3.28, 9.39, and 4.99 respectively. What is more, compared with phased-array probe, the quantitative analysis of high-frequency linear probe is of high reproducibility and could get good curve fitting