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Association among polymorphisms in the apoptosis-related NKX3-1, caspase-3, caspase-9, and BCL-2 genes and prostate cancer susceptibility from 9,706 cases and 12,567 controls
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  • Yanyan Feng,
  • Zhenting Feng,
  • Dan Li,
  • 2† Jiandong Gui1,
  • Zhihong Song,
  • Xiaohua Xie,
  • Lijie Zhu2*,
  • Yuanyuan Mi
Yanyan Feng
Jiangnan University Wuxi School of Medicine
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Zhenting Feng
Shenzhen Second People's Hospital
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Dan Li
Shenzhen Second People's Hospital
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2† Jiandong Gui1
Jiangnan University Wuxi School of Medicine
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Zhihong Song
Shenzhen Second People's Hospital
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Xiaohua Xie
Shenzhen Second People's Hospital
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Lijie Zhu2*
Affiliated Hospital of Jiangnan University
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Yuanyuan Mi
Affiliated Hospital of Jiangnan University

Corresponding Author:[email protected]

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Abstract

Introduction While there is a growing volume of evidence suggesting that relatively prevalent functional polymorphisms present within apoptosis-related genes may influence human prostate cancer (PCa) susceptibility, the clinical relevance of these findings remains inconclusive. This meta-analysis was thus developed with the goal of generating more precise estimates of the relationships between polymorphisms in four apoptosis-associated genes (NKX3‑1, Caspase-3, Caspase-9, and BCL‑2) and the risk of PCa. Material and methods The PubMed, Web of Science, Google Scholar, Embase, Cochrane Library, and SinoMed (CNKI and Wanfang) databases were searched for relevant studies published through December 20, 2023 using the following keywords: ‘polymorphism’ or ‘variant’ and ‘carcinoma’ or ‘cancer’ or ‘tumor’ and ‘NKX3-1’, ‘CASP3’ or ‘Caspase-3’, ‘CASP9’ or ‘Caspase-9’, ‘BCL-2’ or ‘B-cell lymphoma’ and ‘prostate cancer’ or ‘PCa’ or ‘prostate adenocarcinoma’. Results This approach led to the identification of 22 case-control studies related to the association between apoptosis-related gene polymorphisms and PCa susceptibility enrolling 9,706 cases and 12,567 controls. Subsequent analyses revealed that the NKX3-1 rs2228013, CASP9 rs1052571, and CASP9 rs4645982 polymorphisms were associated with greater PCa risk, whereas the CASP3 rs4647603 polymorphism was associated with a risk reduction. Conclusions These findings provide strong evidence for the potential contributions of polymorphisms in the apoptosis-related caspase-3, caspase-9, and NKX3-1 genes in the onset and progression of PCa.
10 Apr 2024Submitted to Cancer Reports
10 Apr 2024Submission Checks Completed
10 Apr 2024Assigned to Editor
10 Apr 2024Review(s) Completed, Editorial Evaluation Pending
16 Apr 2024Reviewer(s) Assigned
13 Sep 2024Editorial Decision: Revise Major
26 Sep 20241st Revision Received
27 Sep 2024Submission Checks Completed
27 Sep 2024Assigned to Editor
27 Sep 2024Review(s) Completed, Editorial Evaluation Pending
27 Sep 2024Reviewer(s) Assigned