Future Directions
Our examination of existing medical literature on ion channelopathies
and their impact on Hispanic/Latino and Indigenous populations indicates
that international and inter-institutional studies have identified
genetic and environmental factors in these groups (Table 1 ).
However, there is a need for additional research to establish a
comprehensive consensus on the effects of genetic variants across
various ethnic subgroups. This understanding can contribute to more
targeted clinical treatments. For example, genome-wide association
studies in Native American and Aboriginal communities could highlight
SNPs in LQTS or other ion channelopathies, as was illustrated in the
Hispanic community. Conversely, multigenerational studies conducted in
Hispanic/Latino communities could provide a more complete picture of
hereditary LQTS. The Hispanic/Latino and Indigenous demographics
comprise a significant portion of the general population, and as such,
more extensive research studies have to be conducted to bridge
healthcare disparities surrounding cardiac ion channelopathies in these
underserved populations.