Study Name Study Design Study Outcome
Risk Factors for Sudden Cardiac Arrest Among Hispanic or Latino Adults in Southern California: Ventura PRESTO and HCHS/SOL16 Case-control study Chronic kidney disease was the top predictor of sudden cardiac arrest risk in Hispanic adult subjects in this study.
Comprehensive Genetic Characterization of a Spanish Brugada Syndrome Cohort24 Retrospective cohort study This study identified 14 Brugada syndrome-susceptibility genes in a Spanish cohort, revealing a higher pathogenic variation discovery yield (32.7%) compared to other European BrS cohorts.
Ethnic Differences in Genetic Ion Channelopathies Associated with Sudden Cardiac Death: A Systematic Review and Meta-Analysis25 Systematic review and meta-analysis There are significant ethnic variations in alleles associated with SCD, with Asians having the highest mean allele frequencies for NOS1AP and SCN5A, Caucasians for KCNH2, and Hispanics for KCNQ1.
GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals26 Meta-analysis This study identified 41 genome-wide significant SNPs across 13 known QT loci and revealed potential novel, population-specific variants at SCN5A and KCNE1.
Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population27 Retrospective cohort study This study on genetic variants in NOS1AP with QT interval to a multi-ethnic population, reveals a significant association in Whites and Blacks and a potential association in Hispanics.
Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA)28 Retrospective cohort study The study explored the effects of NOS1AP variants on QT interval duration in a diverse cohort, finding stronger associations in Caucasians, weaker evidence in Hispanics and Chinese, and potential novel associations at the 3’ end of NOS1AP in Chinese participants.
Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations29 Fine-mapping study The study fine-mapped 16 QT loci in AA and Hispanic/Latino populations, revealing shared and novel population-specific QT signals, emphasizing gene regulatory dysfunction in QT prolongation.
Cardiac arrest with ”pseudo-Brugada” ECG pattern in the setting of a coronary artery anomaly22 Case report and literature review The study describes a case of a Hispanic man with ventricular fibrillation and BrS, whose anomalous origin of the right coronary artery was surgically corrected, leading to the normalization of the Brugada ECG pattern.
A Case of Brugada Syndrome Masquerading as Acute Coronary Syndrome in a Hispanic Male23 Case report This case report described the management of a 58-year-old male with BrS manifesting similarly to acute coronary syndrome after ruling out structural heart diseases.
Prevalence of atrial fibrillation and association with clinical, sociocultural, and ancestral correlates among Hispanic/Latinos: The Hispanic Community Health Study/Study of Latinos14 Population-based prospective cohort study The study found a low overall AF prevalence (1.0%) in a diverse Hispanic/Latino population, indicating varying risks across ethnic backgrounds, with individuals of Dominican and Puerto Rican heritage having higher AF risks than those of Mexican background.
Evaluation of Sudden Cardiac Arrest by Race/Ethnicity Among Residents of Ventura County, California, 2015-202017 Prospective cohort study The study found that the burden of sudden cardiac arrest was similar in Hispanic and White cohorts and lower in Asian cohort and identified shared SCA risk factors among Asian and Hispanic populations.
Validation of PR interval length as a criterion for development of atrial fibrillation in non-Hispanic whites, African Americans and Hispanics18 Retrospective epidemiological study The study validates a PR interval of 200ms as a criterion for predicting AF in AA and Hispanics, but suggests that this value may be less sensitive in predicting AF in AA compared to non-Hispanic Whites.
Are sedentary behavior and physical activity independently associated with cardiometabolic benefits? The Hispanic Community Health Study/Study of Latinos33 Prospective cohort study Hispanics/Latinos without cardiometabolic disease and those who met guidelines for low-to-moderate physical activity experienced a significant decline in LDL-cholesterol and lower fasting glucose levels indicating a population-specific benefit of lifestyle determinants of health.
Confronting the Growing Crisis of Cardiovascular Disease and Heart Health Among Aboriginal Peoples in Canada13 Literature review This literature review article discusses the increasing burden of CVD among Canadian Aboriginal peoples, attributed to dietary changes and reduced physical activity.
The Genetics of Cardiovascular Disease in Canadian and International Aboriginal Populations12 Literature review This study emphasizes the genetic factors influencing CVD in Aboriginal populations, noting distinctions in disease rates, including higher incidences of congenital heart malformations and LQTS in specific communities.
Cardiovascular Disease Burden and Outcomes Among American Indian and Alaska Native Medicare Beneficiaries11 Population-based cohort study This study discusses the significant burden of CVD and cardiometabolic risk factors among American Indian and Alaska Native Medicare beneficiaries.
American Indians and atrial fibrillation34 Literature review This study discusses the heightened risk of AF and AF-related stroke in the American Indian population.
Atrial fibrillation in Indigenous and non-Indigenous Australians: a cross-sectional study35 Retrospective cross-sectional study This study discusses the age-dependent prevalence of AF in Indigenous and non-Indigenous Australians, highlighting significantly higher rates among young Indigenous Australians.
Screening for Atrial Fibrillation in American Indian Adults in a Tribal Primary Care Clinic36 Prospective cohort study This study demonstrates the feasibility and efficacy of opportunistic, mobile single-lead ECG screening for AF in American Indian adults, revealing a higher prevalence of AF than in the usual care group, especially among those under 65, emphasizing the potential benefits of earlier AF screening in this population.
Comparison of QRS Duration and Associated Cardiovascular Events in American Indian Men Versus Women (The Strong Heart Study)37 Prospective cohort study This cohort study compares American Indian men and women, showing that elevated QRS duration is an independent predictor of CVD in women, particularly associated with higher risks of coronary heart disease and myocardial infarction.
A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact38 Comparative study This study, conducted in a remote Canadian First Nations community, identifies a novel KCNQ1 mutation (V205M) associated with hereditary LQTS, leading to variable clinical expression.