Successful management with urgent haploidentical-peripheral blood stem
cell transplantation for a patient with severe aplastic anemia who
developed disseminated fungal infection following immunosuppressive
therapy
Abstract
Urgent haploidentical hematopoietic cell transplantation may be
considered in cases of severe aplastic anemia (SAA) without human
leukocyte antigen-matched donor and suffering from severe infection.
However, deciding on allogeneic transplantation in the setting of active
systemic infection is challenging due to poor outcomes. This report
presents a case of disseminated Magnusiomyces capitatus infection
in a 5-year-old male who underwent immunosuppressive therapy for
hepatitis-associated SAA. To address the critical situation, granulocyte
transfusion was promptly administered from the patient’s mother,
followed by unmanipulated haploidentical peripheral blood stem cell
transplantation from the patient’s father with posttransplant
cyclophosphamide, ultimately resulting in successful rescue.