The impact of different dosages of vitamin E supplementation on
oxidative stress, spatial learning, working memory, and the expression
of aging-related genes in the heart and hippocampus of aged mice.
Abstract
This study conducted an investigation into the impact of
different dosages of vitamin E supplementation on histopathological
alterations, cognitive behaviors, and the expression of age-associated
genes in the heart and hippocampus of aged mice. Mice at 12 months of
age received varying doses of vitamin E (100 mg/kg, 200 mg/kg, and 400
mg/kg) orally through gavage for 28 days. The results indicated that
vitamin E supplementation improved working memory and spatial learning,
reduced oxidative stress in the heart and brain tissues, and positively
influenced the expression of SIRT1, Nrf2, and Calstabin2 genes.
Interestingly, the efficacy of vitamin E was dose-dependent, with higher
doses demonstrating more beneficial effects. The study also examined the
influence of vitamin E on the activities of antioxidant enzymes, such as
SOD and GPX, as well as the levels of MDA, a marker of oxidative stress,
and found that vitamin E supplementation resulted in dose-related
changes in these parameters. The findings also indicate that higher
doses of vitamin E, particularly at 400 mg/kg, demonstrated more
beneficial effects. However, the study emphasizes the need for further
research to confirm these findings and to explore the potential clinical
applications of vitamin E supplementation in addressing age-related
conditions.
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