Objective This study aims to investigate the factors affecting development of acute kidney injury (AKI) due to severe hypothyroidism. Methods This single-centre, retrospective observational study involved patients with primary hypothyroidism and thyroid stimulating hormone (TSH) levels of more than 50 mIU/L at their review in the endocrinology outpatient clinic, between January 2015 and April 2021. Patients whose medical history and laboratory data were complete were included in the study. Demographic and laboratory data of patients with AKI (case group) and without (control group) were compared. Factors affecting the development of AKI were examined by logistic regression analysis. Results A total of 100 patients, 20 (11 male (M), 9 female (F)) in the AKI (case) group and 80 (23 M, 57 F) patients in control group, were included in our study. The median age of the case group (56 years, interquartile range (IQR) 44.3–68.5) was significantly higher than the control group (49 years, IQR 32.3–60; p = 0.027), and the ratio of males to females was significantly higher in the case group (p = 0.001). Multivariate logistic regression analyses showed that hypothyroidism diagnosed after the age of 60 years (odds ratio (OR) 59.674, 95% confidence intervals (CI) 5.955–598.031; p = 0.001), free triiodothyronine (FT3) < 1.3 pg/mL (OR 17.151, 95% CI 2.491–118.089; p = 0.004) and creatine kinase (CK) > 1000 U/L (OR 1.522, 95% CI 1.602–82.848; p = 0.015) were predictors for the development of AKI due to severe hypothyroidism. Conclusion We recommend close follow-up and monitoring of patients with AKI caused by severe hypothyroidism if aged > 60 years, CK > 1000 U/L or FT3 < 1.3 pg/mL.

Purpose: Vitamin D deficiency is a common health problem around the world. This study aimed to evaluate the nationwide prevalence of vitamin D status in tertiary care hospitals in Turkey. Methods: Retrospectively, the data of vitamin D levels from 33 tertiary care hospitals’ clinical biochemistry laboratories around Turkey between 2 January 2016 and 31 December 2016 were conducted. Results: In total 706434 serum samples from adult subjects (F/M: 469028/ 237406; 66.4%/ 33.6%) were included. While vitamin D levels were sufficient in 20.3% (n=14222), they were insufficient in 21.9% (n=154360) and deficient in 57.8% (n=408882). Of the deficient group, 25.0% (176608) had levels <10 ng/mL consistent with profound deficiency. We observed the highest rates of deficiency in those aged between 18-29 years 62.9% (n=70235) and lowest rates in 60-69 years (52.3%, n=61121) and in 70-79 years (52.3%, n=32397). Hypervitaminosis D were consisting of 5.5% of adult subjects. highest rates of hypervitaminosis D were observed in over 80 years (6.6%) and 70-79 years (6.5%), and the lowest in 18-29 years (2.8%). Deficiency rates were 55.4% (n=131468) in men and 59.2% (n=277384) in women. Higher deficiency rates were observed in January (67.9%), February (71.6%), and March (66.7%). Conclusion: In this cohort, over half of the subjects admitted to the tertiary care hospitals in Turkey had vitamin D deficiency, required vitamin D supplementation. The elderly population had the lowest prevalence of vitamin D insufficiency and the highest prevalence of hypervitaminosis D. That may indicate overtreatment of vitamin D supplementation in the elderly group.