Simultaneous changes of PD-1、PD-L1、CTLA-4、TGF-β1、HIF-1α、IL-2、IL-6
in peripheral blood of chemothepy-SCLC and their relation with clinical
characteristics and survival
Abstract
This study was the first to report the prognostic value of PD-1, PD-L1,
CTLA-4, TGF-β1, HIF-1α, IL-2 and IL-6 in peripheral blood on PFS and OS
of SCLC.Few studies had reported the correlation between immune-related
factors and SCLC survival in SCLC studies, while no studies had reported
more than 7 immune-related factors at the same time.We investigated the
changes of IL-2, IL-6, TGF-β1, HIF-1α, PD-1, PD-L1 and CTLA-4 in the
course of chemotherapy compared with healthy controls, the relationships
between each factor and clinical characteristics, the relationships
among the 7 factors, and the relationships between the 7 factors and
survival,prognosis.There were statistical differences in 7 cytokines
between SCLC patients and healthy controls before and during treatment