During first wave of the COVID pandemic, infection prevention measures were enforced at our Pediatric Neuro-Oncology unit. A retrospective study analysing patients booked in this unit during lockdown was performed to describe its performance. There were 438 consultations for 123 patients (320 on-site/118 telephone). Eight new diagnoses, with one significant delay. Only one patient tested positive for SARS-COV2. Delay in imaging testing occurred in 15 patients. Chemotherapy was delayed in one case and not in radiotherapy. Measures implemented were effective in minimizing the risk of COVID-19 infection, achieving continuity in diagnoses and treatment and avoiding delays that could impact survival.