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Comparison of the pregnant and non-pregnant women of reproductive age hospitalised due to COVID 19 infection.
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  • Özgür Kılıç,
  • Mehmet Polat,
  • Eda Kopru,
  • Muzaffer Elmali,
  • Nazmiye Tibel Tuna,
  • ilkay bozkurt,
  • Davut Guven,
  • Melda Dilek
Özgür Kılıç
Ondokuz Mayis University Faculty of Medicine

Corresponding Author:[email protected]

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Mehmet Polat
Nevsehir State Hospital
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Eda Kopru
Ondokuz Mayis University Faculty of Medicine
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Muzaffer Elmali
Ondokuz Mayis University Faculty of Medicine
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Nazmiye Tibel Tuna
Ondokuz Mayis University Faculty of Medicine
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ilkay bozkurt
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Davut Guven
Ondokuz Mayis University Faculty of Medicine
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Melda Dilek
Ondokuz Mayis University Faculty of Medicine
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Abstract

Background: COVID 19 affects pregnant women more severe than the nonpregnant women of reproductive age. However, the rate of critical illness and fatality reported from the other studies varied in a wide range in both group. The study aims to investigate the clinical outcomes of pregnant and nonpregnant patients hospitalised with COVID 19 infection. Method: Clinical, radiologoic and laboratory data of pregnant and nonpregnant patients of reproductive age (18-45 years) infected with COVID 19 were analysed retrospectively. Results: Of 153 patients, 123 were nonpregnant and 30 were pregnant. 15 of the 30 pregnant patients delivered during the hopital stay and 6 of them received an urgent cesarean section. Of the six urgent delivery, five were due to respiratory insufficiency related to COVID 19 and one was unrelated to COVID 19. Four preterm birth, one perinatal death but no stillbirth or miscarriage was recorded. The most common symptom and comorbidity were cough and asthma in both group respectively. Semiquantative CT severity score was significantly higher in pregnants than in nonpregnants (9 points vs 2 points, p=0.022). Prognostic laboratory markers including lymphocytopenia, C-reactive protein and D-dimer were markedly worse in the pregnant group. Severe or critical patients were proportionally higher in the pregnants than in the nonpregnants (26% vs 15%, p=0.004). Hospital length of stay (HLOS) was median 4 vs 5 day; p=0.68, mortality rate was 1/123(0.8%) vs 0/30(0%), p=0.62; intensive care unit (ICU) admission rate was 3/123 (2.4%) vs 7/30 (23.3), p<0.001; need for invasive mechanical ventilation (IMV) was 2/123 (1.6%) vs 5/30 (17%), p=0.003 in nonpregnant and pregnant patients respectively. Conclusion: COVID 19 has a more severe course in pregnant women versus nonpregnant control group, but no difference was noted in terms of hospital length of stay and mortality.