While it is often assumed that oncogenic process in metazoans can influence biotic interactions, empirical evidence for that is lacking. Here, we use the cnidarian Hydra oligactis to experimentally explore the consequences of tumor associated phenotypic alterations for the hydra’s predation efficiency, the relationship with commensal ciliates and the vulnerability to predators. Unexpectedly, the efficiency of hydra predation on prey was higher in tumorous polyps compared to non-tumorous ones. Commensal ciliates colonized preferentially tumorous hydras than non-tumorous ones, and had a higher replication rate on the former. Finally, in a choice experiment, tumorous hydras were preferentially eaten by a fish predator. This study, for the first time, provides evidence that neoplastic growth has the potential, through effect(s) on host phenotype, to alter biotic interactions within ecosystems and should thus be necessarily taken into account by ecologists.