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Vaccine effectiveness against influenza hospitalisation in adults during the 2022/23 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network
  • +36
  • Angela Rose,
  • Francisco Pozo,
  • Iván Martínez-Baz,
  • Clara Mazagatos,
  • Nathalie Bossuyt,
  • John Paul Cauchi,
  • Goranka Petrovic,
  • Isabela Loghin,
  • Roberta Vaikutyte,
  • Silke Buda,
  • Ausenda Machado,
  • Roisin Duffy,
  • Beatrix Oroszi,
  • Jennifer Howard,
  • Aitziber Echeverria,
  • Cristina Salete,
  • Cyril Barbezange,
  • Ausra Dziugyte,
  • Diana Nonkovic,
  • Corneliu Popescu,
  • Fausta Majauskaite,
  • Kristin Tolksdorf,
  • Verónica Gómez,
  • Lisa Domegan,
  • Judit Horvath,
  • Jesus Castilla,
  • Miriam García-Vázquez,
  • Thomas Demuyser,
  • Maria-Louise Borg,
  • Irena Tabain,
  • Mihaela Lazar,
  • Ieva Kubiliute,
  • Ralf Dürrwald,
  • Raquel Guiomar,
  • Joan O Donnell,
  • Katalin Krisztalovics,
  • Nathalie Nicolay,
  • Sabrina Bacci,
  • Esther Kissling
Angela Rose
Epiconcept

Corresponding Author:[email protected]

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Francisco Pozo
Instituto de Salud Carlos III
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Iván Martínez-Baz
Instituto de Salud Pública de Navarra - IdiSNA - CIBERESP
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Clara Mazagatos
Carlos III Health Institute
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Nathalie Bossuyt
Sciensano
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John Paul Cauchi
Ministry of Health Malta
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Goranka Petrovic
Croatian Institute of Public Health
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Isabela Loghin
St Parascheva Clinical Hospital of Infectious Diseases
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Roberta Vaikutyte
Lithuanian University of Health Sciences
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Silke Buda
Robert Koch-Institute
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Ausenda Machado
Instituto Nacional de Saude Doutor Ricardo Jorge
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Roisin Duffy
Health Service Executive-Health Protection Surveillance Centre
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Beatrix Oroszi
Semmelweis University
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Jennifer Howard
Epicentre
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Aitziber Echeverria
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)
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Cristina Salete
Servicio Extremeño de Salud
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Cyril Barbezange
Sciensano
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Ausra Dziugyte
Malta Health Promotion and Disease Prevention Directorate
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Diana Nonkovic
Teaching Public Health Institute of Split-Dalmatia County
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Corneliu Popescu
Dr Victor Babes Clinical Hospital of Infectious and Tropical Diseases
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Fausta Majauskaite
Lithuanian University of Health Sciences
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Kristin Tolksdorf
Robert Koch Institute
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Verónica Gómez
Instituto Nacional de Saude Doutor Ricardo Jorge IP
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Lisa Domegan
Health Service Executive-Health Protection Surveillance Centre
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Judit Horvath
Semmelweis University
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Jesus Castilla
Instituto de Salud Pública y Laboral de Navarra
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Miriam García-Vázquez
Dirección General de Salud Pública, Departamento de Sanidad, Gobierno de Aragón
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Thomas Demuyser
Universitair Ziekenhuis Brussel
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Maria-Louise Borg
Malta Health Promotion and Disease Prevention Directorate
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Irena Tabain
Croatian Institute of Public Health
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Mihaela Lazar
"Cantacuzino" National Military Medical Institute for Research and Development
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Ieva Kubiliute
Vilnius University Institute of Experimental and Clinical Medicine
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Ralf Dürrwald
Robert Koch Institut
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Raquel Guiomar
Instituto Nacional de Saúde, Dr Ricardo Jorge
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Joan O Donnell
Health Service Executive-Health Protection Surveillance Centre
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Katalin Krisztalovics
Semmelweis University
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Nathalie Nicolay
European Centre for Disease Prevention and Control
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Sabrina Bacci
European Centre for Disease Prevention and Control
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Esther Kissling
Epiconcept
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Abstract

We conducted a multicentre hospital-based test-negative case–control study to measure vaccine effectiveness (VE) against PCR-confirmed influenza in adult patients with severe acute respiratory infection (SARI) during the 2022/23 influenza season in Europe. Among 5547 SARI patients ≥18 years, 2963 (53%) were vaccinated against influenza. Overall VE against influenza A(H1N1)pdm09 was 11% (95%CI: -23–36); 20% (95%CI: -4–39) against A(H3N2) and 56% (95%CI: 22–75) against B. During the 2022/23 season, while VE against hospitalisation with influenza B was >55%, it was ≤20% for influenza A subtypes. While influenza vaccination should be a priority for the upcoming season, improved vaccines against influenza are needed.
05 Oct 2023Submitted to Influenza and other respiratory viruses
10 Oct 2023Submission Checks Completed
10 Oct 2023Assigned to Editor
28 Oct 2023Reviewer(s) Assigned