Funding Statement
This work was supported by Chang Jiang Scholars Program (No. Q2021122), Hunan Talent Young Investigator (No. 2019RS2012), Hunan Outstanding Young Investigator (No. 2020JJ2055), CAMS Innovation Fund for Medical Sciences (CIFMS) (No.2021-I2M-1-059, No. 2019-I2M-5-033), the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2020-RC320-003).