Results: 
Between January 2019 and January 2020, 105 children with CF between 4-12 years were seen in clinic and eligible for a PT evaluation. PT collected BOT-2 Test scores on 72 children (69%) over the course of one year. Of the 72 completed evaluations, 7 (10%) were performed at the end of a hospital admission for pulmonary exacerbation and the remainder were tested during a routine outpatient clinic visit. Identified barriers to completing BOT-2 assessment during routine clinic visits included: 1) Poor clinic attendance, 2) Family opting out of participating due to high co-pay for PT assessments, 3) Inappropriate attire/footwear to complete testing, 4) Acute illness, 5) Family declining evaluation due to scheduling conflicts and 6) Lack of PT coverage in clinic due to illness or scheduled vacation.
Demographic data for the 72 evaluated children are included inTable 1 . Children had a median age of 7 years, 90% had at least one F508 mutation. About half were diagnosed with a comorbidity (49%) and 55% had a clinical history of one or more lifetime hospitalizations with 25% having 3 or more lifetime hospitalizations. Spirometry data were available in a subset of children (n=55, 76%). Median [IQR] percent predicted (pp) FEV1 and FVC were 100 [92, 107], and 104 [95.5, 111.5], respectively, at the time of the BOT-2 assessment.
A summary of BOT-2 scores is shown in Table 2 . Eighteen (35%) scored below average (<18%) in either total motor composite (TMC), body coordination (BC) or strength and agility (SA) scores. Decreased SA (18.1%) was the most common delay at the 18% percentile cutoff, followed by TMC (15%) and BC (14%). Overall, these children had a median total motor composite (TMC) score of 50 [IQR: 45 to 56]. This corresponded to a TMC percentile (TMC%) median 50% [IQR: 30%-73%]. Eleven (15%) children scored below the 18th percentile on their TMC and 17 (24%) scored below the 25th percentile. Using the descriptive categories of well below average and below average to indicate impairment, impaired strength (22.2%) was the most common finding, followed by impaired balance (16.7%), impaired running speed and agility (15.3%), and impaired bilateral coordination (8.3%).