Results:
Between January 2019 and January 2020, 105 children with CF between 4-12
years were seen in clinic and eligible for a PT evaluation. PT collected
BOT-2 Test scores on 72 children (69%) over the course of one year. Of
the 72 completed evaluations, 7 (10%) were performed at the end of a
hospital admission for pulmonary exacerbation and the remainder were
tested during a routine outpatient clinic visit. Identified barriers to
completing BOT-2 assessment during routine clinic visits included: 1)
Poor clinic attendance, 2) Family opting out of participating due to
high co-pay for PT assessments, 3) Inappropriate attire/footwear to
complete testing, 4) Acute illness, 5) Family declining evaluation due
to scheduling conflicts and 6) Lack of PT coverage in clinic due to
illness or scheduled vacation.
Demographic data for the 72 evaluated children are included inTable 1 . Children had a median age of 7 years, 90% had at
least one F508 mutation. About half were diagnosed with a comorbidity
(49%) and 55% had a clinical history of one or more lifetime
hospitalizations with 25% having 3 or more lifetime hospitalizations.
Spirometry data were available in a subset of children (n=55, 76%).
Median [IQR] percent predicted (pp) FEV1 and FVC
were 100 [92, 107], and 104 [95.5, 111.5], respectively, at the
time of the BOT-2 assessment.
A summary of BOT-2 scores is shown in Table 2 . Eighteen (35%)
scored below average (<18%) in either total motor composite
(TMC), body coordination (BC) or strength and agility (SA) scores.
Decreased SA (18.1%) was the most common delay at the 18% percentile
cutoff, followed by TMC (15%) and BC (14%). Overall, these children
had a median total motor composite (TMC) score of 50 [IQR: 45 to
56]. This corresponded to a TMC percentile (TMC%) median 50% [IQR:
30%-73%]. Eleven (15%) children scored below the
18th percentile on their TMC and 17 (24%) scored
below the 25th percentile. Using the descriptive
categories of well below average and below average to indicate
impairment, impaired strength (22.2%) was the most common finding,
followed by impaired balance (16.7%), impaired running speed and
agility (15.3%), and impaired bilateral coordination (8.3%).