Textures in Molybdenum-Rhenium alloys are inevitable during thermal fabrication. [110] and [100] are common orientations in Molybdenum-Rhenium alloys and effect mechanical responses. However, orientation dependence of mechanical responses in Molybdenum-Rhenium alloys is not quite clear yet. To clarity this problem, micro-pillar compression tests are conducted in grains with orientation [100] and [110] separately. Orientation-dependent compressive properties are found in Mo-14Re and Mo-42Re, but are not found in Mo and Mo-5Re, which may be attributed to activated muiti-slip planes as increased Re. Solid solution effect of Re not only rely on orientations, but also on Re content. Softening effect occurs in both [100] and [110] Mo-5Re. while, strong strengthening effect happens in [110] Mo-14Re and Mo-42Re. Our research clarifies that Mo-Re alloys with [110] orientation / texture could be preferred to obtain good strengthening effect.