Pre-surgery training, post-surgery baseline analyses, and
non-infusion sessions
A series of independent t -tests considered whether there might be
pre-surgery (Standard condition only) or post-operative training
performance differences between the iDREADDs and GFP-control rats on the
five T-maze task conditions prior to any infusions. The two groups did
not differ significantly on the pre-surgery training nor on the baseline
training prior to commencement of infusion trials for the five test
conditions: all ts < 1.86, ps> 0.078. A further set of t -tests took the scores
from the non-infusion sessions that were interleaved between the saline
and clozapine sessions (Figure 1), for all but the Dark condition.
Again, there were no performance differences between the iDREADDs and
GFP-control animals on the infusion-free days for each of the four
conditions: all ts < 1.01, ps> 0.29.