Purpose:Aspergillus basicranial infection is a rare disease, often associated with delayed or unproven diagnosis, the management of which is unclear. Methods:We report a probable case of otogenic skull base aspergillus osteomyelitis,review invasive basicranial osteomyelitis,manage and follow up the patient by galactomannan(GM) test and magnetic resonance imaging(MRI) during the treatment of voriconazole. Results: