Infective endocarditis with splenic abscesses remains a complex and unusual clinical scenario. We present a rare case of splenic hematoma caused by puncture and drainage of splenic abscess with infective endocarditis. The puncture drainage of the splenic abscess may lead to bleeding or the spread of infection. So when infective endocarditis is complicated with splenic abscess, splenectomy rather than drainage of the splenic abscess is preferred to lower the risk of splenic hemorrhage and eradicate the source of infection.